A brief analysis of chitin synthesis inhibiting insecticide buprofezin
What is buprofezin (69327-76-0)?
The pesticide buprofezin is a new selective insecticide that inhibits the growth and development of insects. It has strong contact killing effect and also has stomach poisoning effect. The mechanism of action of Cas 69327-76-0 is to inhibit chitin synthesis and interfere with metabolism of insects, causing nymphs to peel. Later deformity or adult wing deformity leads to slow death. Generally, the pesticide will take effect 3 to 7 days after application. It has no direct lethality to adults, but it can shorten the life span and reduce the number of eggs laid. Most of the eggs produced are infertile, and the larvae will die quickly even if they hatch.
The insecticide buprofezin is highly selective and has good control effect against homoptera planthoppers, leafhoppers, whiteflies and scale insects. It also has long-lasting larvicidal activity against certain coleopteran pests and harmful mites. . It can effectively control planthoppers and leafhoppers on rice, tea, leafhoppers on potatoes, whiteflies on citrus and vegetables, shield scales and mealybugs on citrus, and can also control scale insects on fruit trees and tea trees. wait. The drug is effective for more than 30 days. It is safer against natural enemies of pests and has a good comprehensive effect. No cross-resistance issues with other insecticides.
The pesticide buprofezin is a low-toxic pesticide. The acute oral LD50 of the original drug in male and female rats is 2198 mg/kg body weight and 2355 mg/kg body weight respectively. Mild eye and skin irritation. It has no teratogenic, mutagenic or carcinogenic effects within the test dose. No abnormalities were found in the two-generation breeding test. It has low toxicity to fish and birds.
Main dosage forms of buprofezin (69327-76-0)
Insecticide buprofezin 5%, 20%, 25%, 50%, 65%, 80% wettable powder, 5%, 10%, 20%, 25% emulsifiable concentrate, 20%, 40%, 50% gel suspension Agent, 20%, 40%, 70% water dispersible granules, 8% film spreading oil agent.
Physicochemical properties of buprofezin (69327-76-0)
(1) Appearance and properties: white crystal (industrial product is white to light yellow crystalline powder)
(2) Relative density: 1.18 (20℃ water = 1)
(3) Vapor pressure: 1.25×10-3Pa (25℃)
(4) Melting point: 104.5～105.5℃
(5) Solubility: 9mg/L in water (20℃), 520g/L in chloroform, 370g/L in benzene, 320g/L in toluene, 240g/L in acetone, 80g/L in ethanol, 20g in hexane /L (both 25℃)
(6) Stability: stable to acids and alkalis, stable to light and heat
Mechanism of action of buprofezin (69327-76-0)
The insecticide buprofezin is an insect chitin synthesis inhibitor. Mainly by inhibiting the synthesis of chitin in insects and interfering with the normal metabolism of insects, it hinders the formation of new epidermis of insects, causing nymphs to molt abnormally and die slowly. It has strong contact and stomach poisoning effects, high insecticidal activity, only kills insects, is safe to humans, livestock and aquatic organisms, and is relatively safe against natural enemies of insects. The drug is slow to take effect and reaches its peak dose about a week after application. It has special effects on Homoptera planthoppers, leafhoppers, mealybugs and scale insect pests. It has persistent effects on Coleoptera, some Homoptera and acarid larvae. It is not lethal to adults, but can reduce egg laying and It hinders the hatching of insect eggs and has no cross-resistance with neonicotinoid insecticides and pyrethroid insecticides. Commonly used for pest control of rice and vegetables.
The role of buprofezin (69327-76-0)
The insecticide buprofezin is a heterocyclic insect chitin synthesis inhibitor that destroys the formation of new epidermis of insects, interferes with the normal growth and development of insects, and causes the death of pests. It has strong contact and stomach poisoning effects and is penetrable. It does not kill adult insects, but it can reduce egg laying and prevent eggs from hatching. The effect of the drug is slow, and it takes 3-7 days to reach the peak dose after taking the drug.
The insecticide buprofezin is an insecticide with persistent larvicidal activity against Coleoptera, some Homoptera and Acarina. It can effectively control the leafhoppers and planthoppers on rice; the leafhoppers on potatoes; the mealybugs on citrus, cotton and vegetables; the scales, shield scales and mealybugs on citrus. . This product is effective against planthoppers, leafhoppers, whiteflies and scale insects of the order Homoptera.
The insecticide buprofezin is suitable for crops such as rice, fruit trees, tea trees, vegetables, etc.
Functional characteristics of buprofezin (69327-76-0)
1. The insecticide buprofezin has strong selectivity against pests. It is only effective against Hemiptera planthoppers, leafhoppers, whiteflies and scale insects, but not against natural enemies.
2. The insecticide buprofezin has a strong contact killing effect and a strong stomach poisoning effect on pests. It has a certain penetration ability for crops and can be absorbed by rice leaves or leaf sheaths, but cannot be absorbed and transmitted by the root system. It has strong poisoning ability against young nymphs, but its poisoning ability against nymphs above the third age is significantly reduced. It has no direct poisoning effect on adult insects. However, it can shorten the lifespan of adults, reduce the number of eggs laid, reduce the hatching rate of eggs produced, and hatch out larvae that die quickly, thus reducing the number of the next generation.
3. The effect of the drug is slow to develop, usually 3-5 days after application. The nymphs begin to die only when they shed their skin, and the number of deaths reaches a peak 7-10 days after the application of the pesticide. Therefore, the drug has a long efficacy period. Generally, the period of direct control of insects is about 15 days. In addition, the protection of natural enemies can exert the effect of natural enemies in controlling pests. So the total validity period can be about 1 month.
4. The pesticide buprofezin is a selective insecticide that inhibits the growth and development of insects. It has a strong contact killing effect on pests and is also stomach poisoning. It has a certain penetration ability into crops and can be absorbed by crop leaves or leaf sheaths, but cannot be absorbed and transmitted by the root system. It has strong poisoning ability against young nymphs, but its poisoning ability against 3-year-old nymphs is significantly reduced, and it has no direct lethality against adults. However, it can shorten its lifespan and reduce the number of eggs it lays. Most of the eggs laid are infertile, and even the hatched larvae will die quickly, thus reducing the number of the next generation.
Main uses of buprofezin (69327-76-0)
The pesticidebuprofezin belongs to the insect growth regulator class of insecticides. It is mainly used for pest control in rice, fruit trees, tea trees, vegetables and other crops. It has persistent larvicidal activity against Coleoptera, some Homoptera and Acarina. It can effectively control leafhoppers and planthoppers on rice; leafhoppers on potatoes; mealybugs on citrus, cotton and vegetables; scales, shieldworms and mealybugs on citrus.
The insecticide buprofezin is a thiadiazine insect growth regulator and an insect molting inhibitor. By inhibiting the synthesis of chitin and interfering with metabolism, the pests cannot molt and metamorphose normally and gradually die. It has the characteristics of high activity, high selectivity and long residual effect. It has special effects on planthoppers, leafhoppers and whiteflies. It also has good effects on some scale insects such as the sagittal scale and Landrace scale. It is mainly used to control rice leafhoppers and planthoppers, potato leafhoppers, citrus, cotton and vegetable whiteflies. , citrus shield scales and mealybugs. For example, to control rice brown planthopper, use 25% wettable powder 3 to 4.5g/100m2 from the egg hatching stage to the young nymph stage, and spray water on the main harmful parts of the pest. It can also control white-backed planthoppers and leafhoppers. wait. To control tea leafhoppers, black thorn whiteflies, orange gall mites, etc., spray 25% wettable powder 750 to 1500 times during the non-picking period of tea leaves and the young stages of insects. This medicine is sensitive to cabbage and radish, so care should be taken when using it.
buprofezin (69327-76-0) Environmental Transport, Diffusion and Transformation
When the pesticide buprofezin enters the environment, buprofezin is digested quickly in the plant, with a half-life of 2 to 3 days; it remains in the soil for a long time, with a half-life of 13 to 14 days. After spraying in rice fields for a long time, it was found that pesticides can remain in brown rice, chaff, and stems, and enter the soil and water environment with spraying and rainwater, causing pollution to migrate and spread. Since buprofezin is relatively stable to light and heat, It also causes air pollution when sprayed.
buprofezin (69327-76-0) application technology
(1) For the main generation of rice planthoppers and leafhoppers and the previous generation, from the egg hatching stage to the young nymph stage, use 20-30 grams of 25% wettable powder per mu, add 40-50 liters of water and spray , focus on spraying the middle and lower parts of the rice plant.
When there are many migration peaks of rice planthoppers, and adults, young and old nymphs coexist, it can be mixed with methiocarb, promethiocarb, isopropylcarb, etc. to treat both old nymphs and adults at the same time. Use 25 grams of 25%buprofezin wettable powder per mu, add 75-100 grams of 25% methiocarb wettable powder, or 35-50 ml of 50% methiocarb emulsifiable concentrate, and spray it with water.
To control rice planthoppers, it is more effective and convenient to use film-forming oil. Generally, 8% film-forming oil and 100-150 ml of wine drops per mu can be used.
(2) When the 2-3 instar nymphs of the greenhouse whitefly are in full bloom, spray with 25% wettable powder 1500-2000 times liquid, and spray again every 15 days depending on the insect situation. Prevent the liquid from falling on cabbage and radish, which may cause brown spots and whitening of green leaves.
(3) Use 25% wettable powder 1500-2000 times to spray citrus rust ticks, panonychus mites, sagittal scales, whiteflies, and black thorn whiteflies.
(4) For tea green leafhoppers, spray them with 25% wettable powder 800-1200 times liquid during the nymph peak period or after picking spring tea, first around the tea tree and then in the middle. Depending on the insect situation, spray again every 10-15 days.
Application ofbuprofezin (69327-76-0) in vegetable production
The insecticide buprofezin is mainly used to control whitefly, green leafhopper, cotton leafhopper, whitefly, green planthopper, white-backed planthopper, gray planthopper, polyphagous tarsal line mite, and type B tobacco powder. lice, greenhouse whitefly, etc.
① To control whiteflies, spray with 10% buprofezin emulsifiable concentrate 1000 times.
②. Use 20% buprofezin wettable powder (emulsifiable concentrate) to spray to control small green leafhoppers and cotton leafhoppers. Use 1000 times liquid spray. To control whitefly, use 1500 times liquid spray. To control green planthoppers, white-backed planthoppers, gray planthoppers, etc., spray with 2000 times liquid.
③. Use 25%buprofezin wettable powder (emulsifiable concentrate) to spray to control polyphagous tarsal line mites (tea mites), and spray with 2000 times the solution. To control type B tabaci and greenhouse whitefly, spray with 1000-1500 times liquid.
④. Mixed spray to control whitefly, use 25% buprofezinthrin wettable powder 1500 times liquid and 2.5% bifenthrin EC 5000 times mixed spray.
How to use buprofezin (69327-76-0)
Insecticide buprofezin foliar spray, 50~600gAI/ha; foliar powder spraying, 450~600g/ha; submerged application (submerged application), 600~800g/ha. For example, 25% buprofezin wettable powder can control planthoppers, leafhoppers, greenhouse mealybugs, etc. on rice and vegetables at a dose of 375-750g/ha, and 800-1000g/ha can control scale insects on fruit trees and tea. The duration of effect is 35 to 40 days. It is safe to natural enemies and flower-visiting insects. It has no cross-resistance with other insecticides. However, it acts slowly. The pest damage can only be controlled 3 to 7 days after application. Therefore, when the insect population density is high, it should be used with Mix fast-acting insecticides.
1. Prevention and control of rice pests
① Rice planthoppers and leafhoppers: Spray once during the prime period of the main pest generation, young nymphs, use 20-30g of Youled 25% wettable powder per acre (active ingredient 5-7.5g), mix with 5-10kg of water , low-volume spray or constant spray mixed with 40-50kg of water, focusing on the middle and lower parts of the plant.
② To control rice brown planthopper, buprofezin should be used in the main generation and its previous generation, from the egg hatching stage to the young nymph stage, using 20 to 30 grams/acre of 25% wettable powder, and add water to the main pest-infested parts. (The middle and lower parts of the rice plant) can be sprayed evenly once each to effectively control the damage. Applying pesticides at the beginning of the peak period of the main nymphal generation of brown planthoppers can also control white-backed planthoppers and leafhoppers, and the effect can reach 81-100%.
2. Control of fruit tree pests: To control citrus sagittal scales, use 25% wettable powder 1,500 to 2,000 times liquid (125 to 167 mg/kg) to spray evenly during the peak period of young nymphs, and the effect is good.
3. Prevention and control of tea pests: To control tea green leafhoppers, black spiny whiteflies, Landrace scales, tea orange gall mites, etc., use it during the non-picking period of tea leaves, when young nymphs or nymphal mites are in full bloom, and when the density of insect mites is high. 25%buprofezin wettable powder 750~1000 times liquid (250~333mg/kg). When the density of insect mites is low, even spraying with 1000 to 1500 times of liquid (167 to 250 mg/kg) can effectively control the damage of insect mites.
4. Tetrazin is used to control whiteflies on greenhouse cucumbers, tomatoes and other vegetables. During the peak period of young nymphs, spray evenly with 2000-2500 times of 25% wettable powder (100-125 mg/kg), which has good control effects. It can also treat tea yellow mites, etc.
5. To control whiteflies on vegetable pests, spray with 10% buprofezin emulsifiable concentrate 1000 times. Or use 25%buprofezin wettable powder 1500 times liquid and 2.5% bifenthrin EC 5000 times mixed and spray.
To control small green leafhoppers and cotton leafhoppers, spray 1000 times of 20% buprofezin wettable powder (emulsifiable concentrate).
To control whitefly, spray with 1500 times of 20% buprofezin wettable powder (emulsifiable concentrate).
To control green planthoppers, white-backed planthoppers, striate planthoppers, etc., spray with 2000 times of 20% buprofezin wettable powder (emulsifiable concentrate).
To prevent and control polyphagous tarsal line mites (tea mites), spray with 2000 times of 20%buprofezin wettable powder (emulsifiable concentrate).
To control type B tabaci and greenhouse whitefly, spray with 1000-1500 times of buprofezin wettable powder (emulsifiable concentrate).
6. To control scale insects and whiteflies such as citrus sagittal scales and whiteflies on fruit trees, use 25% buprofezin suspension (wettable powder) 800~1200 times liquid or 37% buproazinone suspension 1200~1500 times spray. When controlling scale insects such as the sagittal scale, spray before the pests emerge or in the early stages of nymph emergence. Spray once per generation. When controlling whiteflies, start spraying from the beginning of whiteflies, once every 15 days, and spray twice in a row, focusing on the back of the leaves.
To control scale insects and small green leafhoppers such as the peach, plum, and apricot mulberry scales, use 25%buprofezin suspension (wettable powder) 800 to 1200 times liquid or 37% buprofezin suspension 1200 to 1500 times the solution spray. When controlling scale insects such as the white mulberry scale insect, spray pesticides promptly after the nymphs hatch to the young nymph stage. Spray once per generation. When controlling small green leafhoppers, spray in time when the pest is at its peak or when more yellow-green dots appear on the front of the leaves. Once every 15 days, spray twice in a row, focusing on the back of the leaves.
7. Rice pest control: rice white-backed planthoppers and leafhoppers: spray once when the main pest generation of young nymphs begins to flourish. Use 50 grams of 25%buprofezin wettable powder per acre, mix with 60 kilograms of water and spray evenly. Focus on spraying the middle and lower parts of the plant.
To prevent and control rice brown planthopper, spraying once each from the egg hatching period of the main generation and the previous generation to the peak emergence period of young nymphs can effectively control its damage. Use 50 to 80 grams of 25% buprofezin wettable powder per acre, mix with 60 kilograms of water and spray, focusing on the middle and lower parts of the plants.
8. When controlling tea tree pests such as green leafhoppers, black thorn whiteflies and gall mites, use pesticides during the non-picking period of tea leaves and the young stages of pests. Spray evenly with 1000-1200 times of 25%buprofezin wettable powder.
Possible risks during the use of buprofezin (69327-76-0)
1 Environmental risks
Since buprofezin is relatively stable to light and heat and has a long lasting effect, it is difficult to decompose after entering the environment and can cause pollution. The human body is exposed through contact with contaminated water sources and food, and contacts can cause subchronic toxicity. After long-term exposure to a polluted environment, workshop production workers may develop symptoms of subchronic nervous system poisoning such as abnormal biceps nerve reflexes.
2 Risk of resistance
In currently monitored areas (major rice-producing areas across the country), all populations of white-backed planthoppers are at moderate to high levels of resistance to the insect growth regulator buprofezin and the organophosphorus chlorpyrifos (resistance multiples to buprofezin are 42 to 160 times, the resistance multiple to chlorpyrifos is 15 to 240 times); it is sensitive to moderately resistant to the neonicotinoid agents imidacloprid, thiamethoxam, and dinotefuran (the resistance multiple to imidacloprid is 2.1 to 18 times, and to thiamethoxam The resistance multiple is 2.0 to 10.1 times, and the resistance multiple to dinotefuran is 1.3 to 12 times).
Brown planthoppers have developed high-level resistance to buprofezin, and it is recommended that all rice areas suspend the use of buprofezin to control white-backed planthoppers to delay the development of resistance. Considering that the toxicity of neonicotinoids to white-backed planthoppers is still very high, when the field rice planthopper population is dominated by white-backed planthoppers, thiamethoxam, dinotefuran, nitenpyram, trifluoride can be used Phenylpyridine and other chemicals are used to control white-backed planthoppers.
The difference between buprofezin (69327-76-0) and thiazinamide
Tetrazinone and thiazinamide are two high-quality pesticides evolved on the basis of imidacloprid. They are broad-spectrum, efficient, low-toxic, and low-residue biological pesticide preparations derived from tobacco plants. extract.
After the plant leaves absorb the pesticide, it can be quickly transmitted to various parts. After the pests absorb the pesticide, their activities are quickly inhibited, stop feeding, and gradually die. These three pesticides are particularly effective against pests with magnetic mouthparts, such as aphids, planthoppers, thrips and other pests. Tetrazinone and thiazinamide are effective against a variety of pests with chewing mouthparts, such as grubs, cutworms, and mole crickets. , money bugs, hard-shelled bugs, etc. also have good control effects, with high efficiency and low dosage per unit area. The special effect period can reach about 30 days.
① buprofezin and thiazinamide are both products produced by the upgrading of imidacloprid. Before imidacloprid andbuprofezin can take effect, they must first be converted into thiazinamide in order to exert their insecticidal effect.
②The price difference betweenbuprofezin and thiazinamide. Due to the difference in production process and the cost of intermediates added during the extraction process, the cost ofbuprofezin is much higher than that of thiazinamide, and the price is more expensive.
③The insecticidal speed of buprofezin is relatively slow, and it takes 24 to 48 hours to kill the pests. The main reason is that the stomach poisoning effect is obvious, but the contact killing effect is not obvious. Thiazinamide kills insects very quickly compared with buprofezin. Generally, it only takes 1 to 2 hours to kill insects.
④The systemic properties of thiazidinone and thiazinamide are different. Thiazinamide is somewhat more systemic than buprofezin. This is the specific reason why thiazinamide is much more potent than buprofezin.
⑤ Tetrazinone and thiazinamide, in addition to killing aphids, planthoppers, thrips and other straw-mouthed pests, when killing hard shell insects or underground pests, thiazinamide can kill insects faster thanbuprofezin. It's fast because it has a very strong killing effect.
⑥ Whenbuprofezin and thiazinamide are used as soil treatment agents, the leaching property of thiazinamine is several times that ofbuprofezin and the action time is long. Thiazinamide is in the soil, and its adsorption capacity with the soil is stronger than that ofbuprofezin. It can withstand rain, floods, and flood irrigation without loss or failure.
Precautions for use of buprofezin (69327-76-0)
①. The insecticide buprofezin has no systemic conduction effect and requires uniform and thoughtful spraying.
②. Do not use it on cabbage and radish, otherwise it will cause brown or albino damage.
③. It should not be used multiple times, continuously, or in high doses. Generally, it should only be used once or twice a year.
④. The medicine should be kept in a cool, dry place and out of the reach of children.
⑤. This medicine should only be used as a spray and cannot be used as a poisonous soil method.
⑥. If you feel uncomfortable during use, you should stop working immediately, leave the pesticide application site, take off your work clothes, and rinse contaminated skin and eyes with clean water. If swallowed by mistake, induce vomiting immediately and send to the hospital for symptomatic treatment. There are no special medications.
⑦. It is poisonous to silkworms and some fish. It is prohibited in mulberry gardens, silkworm rooms and surrounding areas to prevent the liquid from contaminating water sources and rivers. It is prohibited to discharge pesticide application field water and waste liquid from cleaning pesticide application equipment into rivers, ponds and other waters.
⑧. The general crop interval is 7 days, and it can be used twice more per crop season.
Insecticide buprofezin (69327-76-0) price
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