A brief analysis of neonicotinoid insecticide nitenpyram
What is nitenpyram (150824-47-8)?
The pesticide Nitenpyram is a neonicotinoid insecticide with unique chemical and biological properties. It mainly acts on insect nerves and has a nerve-blocking effect on pest synaptic receptors. It is used in crops such as rice and vegetables. It shows excellent activity against various aphids, whiteflies, rice leafhoppers and thrips, and has high efficiency and low toxicity. , systemic and no cross-resistance, and has a wide insecticidal spectrum and a long residual period (applied at 100mg/kg, it can last for 15 days.
The insecticide nitenpyram has the advantages of ultra-high efficiency, broad spectrum, low dosage, low toxicity (slightly toxic preparation level), long-lasting effect, no harm to crops, and safe use. Its aphids-killing effect is unparalleled among others. It is more than 10 times that of pesticides. It is a new variety promoted in China in recent years to replace highly toxic organophosphorus pesticides. Nitenpyram is another new product developed after imidacloprid and acetamiprid. It has excellent systemic properties, penetration, broad insecticidal spectrum, and is safe and non-toxic.
Nitenpyram is a nicotinic acetylcholinesterase receptor inhibitor with systemic and osmotic effects. It mainly acts on insect nerves, inhibits acetylcholinesterase activity, acts on cholinergic receptors, and expands after spontaneous discharge. The diaphragm position difference reduces the stimulation of the synaptic diaphragm, resulting in the loss of stimulation of the neuraxial synaptic diaphragm potential channel of the nerve. It has a nerve blocking effect on the neuraxial synaptic receptors of insects, causing paralysis and death of pests. Due to the high water solubility and low partition coefficient of nitenpyram, nitenpyram has low toxicity to animals, and most of its metabolites can be excreted with metabolism in the body.
Nitenpyram (150824-47-8) Physical and Chemical Properties
The insecticide nitenpyram is a light yellow crystal, Cas 150824-47-8, with a melting point of 83-84°C and a density of 1.40 (26°C). Vapor pressure 1.1×10-9Pa (25℃). Solubility (g/L, 20℃): water (pH=7) 840, chloroform 700, acetone 290, xylene 4.5.
toxicity
Rat acute oral LD50: male 1680 mg/Kg, female 1575 mg/Kg; mouse acute oral LD50: male 867 mg/Kg, female 1281 mg/Kg; rat acute dermal LD50: male and female >2000 mg/Kg ; Rat inhalation LC50 (4 hours): 5.8g/L; This product has slight irritation to rabbit eyes but no irritation to rabbit skin. No teratogenic, mutagenic or carcinogenic effects.
NOEL data: rats (2 years) male 129, female 53.7 mg/Kg b.w. day. Dogs (1 year) 60 mg/Kg b.w. day.
Nitenpyram (150824-47-8) mechanism of action
The insecticide nitenpyram is an inhibitor of nicotinic acetylcholinesterase receptors. It has systemic and osmotic effects. It mainly acts on insect nerves, inhibits the activity of acetylcholinesterase, and acts on cholinergic receptors. It acts on spontaneous After discharge, the diaphragm potential difference is expanded and the stimulation of the synaptic diaphragm is reduced, resulting in the loss of stimulation of the axial synaptic diaphragm potential channel of the nerve. It has a nerve blocking effect on the neuraxial synaptic receptors of insects, causing paralysis and death of pests. Due to the high water solubility and low partition coefficient of nitenpyram, nitenpyram has low toxicity to animals, and most of its metabolites can be excreted with metabolism in the body.
Nitenpyram (150824-47-8) target crops
The insecticide nitenpyram can be widely used in agriculture and horticulture such as rice, fruit trees, vegetables and tea to prevent aphids, rice planthoppers, whitefly, leafhoppers, thrips and other piercing-sucking mouthpart pests. It has the characteristics of super high efficiency, broad insecticidal spectrum, unique mode of action, low dosage, low toxicity, long-lasting efficacy, no harm to crops, low toxicity to humans, and safe use. Its advantage is that it has no cross-resistance with the mainstream neonicotinoid insecticides imidacloprid and thiamethoxam.
Nitenpyram (150824-47-8) registration
The pesticide nitenpyram currently has a total of 170 nitenpyram products approved by the Ministry of Agriculture and Rural Affairs and still within the validity period, of which 17 are registered as original drugs. Nitenpyram products sold on the market include water-dispersible granules, soluble formulations, soluble powders, soluble granules, aqueous formulations, wettable powders and ultra-low volume liquid formulations. It is widely used for the control of sucking pests with mouthparts such as rice, cotton and fruit trees.
The insecticide nitenpyram has synergistic and insecticidal and acaricidal effects after being mixed with pesticides such as organophosphorus, carbamate, and nereworm poisons that some pests have developed resistance to. Its applicable crops are rice, cotton, vegetables, fruit trees, tea, etc. It can be used for both stem and leaf treatment and soil treatment.
Nitenpyram (150824-47-8) performance characteristics
The insecticide nitenpyram is a nicotinimide and is another new product developed after imidacloprid and acetamiprid. It has excellent systemic properties, penetration, broad insecticidal spectrum, and is safe and non-toxic. It is an alternative product for controlling sucking mouthpart pests such as whiteflies, aphids, pear psyllids, leafhoppers and thrips.
What are the advantages and disadvantages of nitenpyram (150824-47-8)
advantage:
The insecticide nitenpyram has a relatively wide insecticidal spectrum and is mainly used to control sucking pests, such as aphids, rice planthoppers, whitefly, whitefly, pear psyllid, leafhoppers, etc. In addition, Can control thrips and other pests.
The insecticide nitenpyram can be used on many crops, such as rice, wheat, apples, citrus, pears, grapes, cucumbers, eggplants, tomatoes, tea and other crops.
Nitenpyram has high safety, low toxicity, and low toxicity to the human body. It has no harmful effects on crops when used at high levels. It is safer than imidacloprid among similar agents and has good systemic properties. Once used, it will Application of pesticides will quickly spread to all parts of the plant, and the insecticidal effect will be more comprehensive and better.
shortcoming:
The pesticide nitenpyram is prone to phytotoxicity when used at high temperatures, so when spraying, avoid high temperatures and choose to spray in weather below 30 degrees.
Another disadvantage of the insecticide nitenpyram is that it has a short duration of effect. Therefore, it may not take long after spraying before it may need to be sprayed again. Moreover, nitenpyram only has systemic and penetrative effects, but no contact killing effect. The killing speed is not as fast as the contact killing type. Single use will also cause resistance, so it is generally recommended to mix the agents to achieve better results.
We can combine nitenpyram with contact-killing and long-lasting agents, such as pymetrozine, bifenthrin, abamectin, buprofen, etc., which can not only increase the duration of effect, but also Speed up insecticide and slow down the development of resistance.
Nitenpyram (150824-47-8) insecticidal advantages
1. Fast insecticide
The insecticide nitenpyram mainly acts on the nervous system of insects. It has a nerve-blocking effect on the synaptic receptors of pests, expands the diaphragm potential difference after spontaneous discharge, and reduces the stimulation of the synaptic diaphragm. As a result, the stimulation of the synaptic diaphragm potential channel of the nerve disappears, causing paralysis and death of the pest.
2. Broad insecticidal spectrum
The insecticide nitenpyram has good control effects on sucking mouthpart pests such as whiteflies, aphids, pear psyllids, leafhoppers, thrips, etc.
3. Safe and efficient
The pesticide nitenpyram is very safe for crops, especially for fruit-bearing trees, with a relatively short residue period.
4. Strong permeability
The insecticide nitenpyram has systemic conductivity and very strong permeability. After application, it can be quickly transmitted and directly attack the pests.
5. Applicable to a wide range of crops
It can be used for field crops, cash crops, orchards, tea gardens and other crops.
How to use nitenpyram (150824-47-8)
1. Use the insecticide nitenpyram to control aphids: Spray evenly with 10% soluble liquid or 2000~3000 times of 10% aqueous solution. You can also use 2000 times of 10% nitenpyram soluble granules to irrigate the roots, which has a good control effect on greenhouse cucumber aphids. The insect population reduction rate exceeded 96% in 10 days after treatment. The validity period can reach more than 20 days.
2. Use the insecticide nitenpyram to control whitefly and whitefly: spray evenly with 10% nitenpyram soluble liquid 2000, or water 10% nitenpyram aqueous solution 2000~3000 times during planting. . For fields with overlapping generations (adults, nymphs, eggs) and a high insect population base, the control effect is outstanding, and the duration of the effect can reach about 20 days.
3. Use the insecticide nitenpyram to control thrips: use 10% nitenpyram soluble liquid diluted 3000 times + 5% acetamiprid 2000 times and spray evenly. The prevention and control effect is outstanding.
4. Use the insecticide nitenpyram to control plant lice: During the outbreak period of plant lice, spray evenly with 10% nitenpyram 2000 times, the control effect is over 90%, and the effect is significantly better than 30% acetamiprid. The quick-acting effect is very obvious, and the lasting effect can reach about 15 days.
Nitenpyram (150824-47-8) uses
The insecticide nitenpyram is a neonicotinoid insecticide with unique chemical and biological properties. It mainly acts on insect nerves and has a nerve-blocking effect on pest synaptic receptors. It is used in crops such as rice and vegetables. It shows excellent activity against various aphids, whiteflies, rice leafhoppers and thrips, and has high efficiency and low toxicity. It has four major advantages: , systemic and no cross-resistance. It also has a wide insecticidal spectrum and a long residual period (applied at 100 mg/kg, lasting 15 days). It is lethal to rice planthoppers at 0.5 to 0.8 mg/kg. The rate can still reach 100%, it is safe to use, and pests are not easy to produce antibodies.
Nitenpyram (150824-47-8) compound
The insecticide nitenpyram is a nicotinic insecticide and has good compounding properties with other pesticides. In order to improve the efficacy, expand the pesticidal scope and delay drug resistance, it can be compounded with other pesticides. The more excellent formulations include: 25% pymetrozine wettable powder, 80% pymetrozine water-dispersible granules, 70% pymetrozine water-dispersible granules, 25% pymetrozine water-dispersible granules, Biphenyl soluble agent, 15% avitamin·pyridine wettable powder, 30% avitamin·pyrimidine wettable powder, 20% avitamin·thiacloprid water dispersible granules, etc. When used, these recipes are rotated.
Synthesis process of nitenpyram (150824-47-8)
2-Chloro-5-chloromethylpyridine is a pesticide intermediate for the synthesis of nitenpyrid. It is not only used for the synthesis of nitenpyrid, but also for other neonicotinoid pesticides such as imidacloprid, acetamiprid, thiacloprid, etc. Important intermediates.
There are two main synthesis processes:
Both routes first synthesize the key intermediate N-(6-chloro-3-pyridylmethyl)-N-ethylamine (intermediate 2). The first route first synthesizes the key intermediate N-(6-chloro-3-pyridylmethyl)-N-ethylamine (intermediate 2). -2-Nitroethylene synthesizes intermediate 3. The second route is to first prepare intermediate 4 through 1,1-dichloro-2-nitroethylene, and finally react with methylamine to obtain the final product nitenpyram.
Compared with synthesis route 1, synthesis route 2 has the advantages of easy availability of raw materials, mild reaction conditions, low production cost, and good product quality.
Nitenpyram (150824-47-8) Precautions
1. The insecticide nitenpyram cannot be mixed with alkaline agents (such as lime sulfur mixture). In use, nitenpyram cannot be mixed with alkaline agents (such as lime sulfur mixture). After mixed with alkaline agents, it is easy to Phytotoxicity occurs and is toxic to bees, fish, aquatic organisms, and silkworms. Apiaries, mulberry gardens and other places need to be avoided when using pesticides.
2. If the insect infestation is serious, it is recommended to use a high-content pesticide compounded with other insecticidal ingredients. The insecticidal effect will be better. Finally, we need to pay attention to the use of nitenpyram. Some cat friends mentioned that low content is not effective. If the insect infestation is serious, It is recommended to use high-content nitenpyram or other insecticidal ingredients, such as pymetrozine and bifenthrin, to achieve stronger insecticidal effects.
2. Pay attention to the number of times of use and the safe interval. The number of times nitenpyram should be used in each crop cycle should not be too many, up to 4 times, to avoid phytotoxicity due to too many times of use, and the safe interval of nitenpyram The period is 7-14 days.
Insecticide nitenpyram (150824-47-8) price
Under normal circumstances, the price of the pesticide nitenpyram will be affected by raw materials, market environment, R&D costs, etc. If you want to know the latest price of the pesticide nitenpyram you need, please contact us to initiate an inquiry.
Tel: 13563082345 Email: sales@agripesticide.com
Insecticide nitenpyram (150824-47-8) supplier
Agripestcide is a professional agrochemical manufacturer that provides various products such as herbicides, insecticides, microbial fungicides, and plant growth regulators. If you are looking for the pesticide insecticide Nitenpyram, please feel free to contact us for the latest price.