Benzoylurea fluorinated nitrogen-heterocyclic insecticide—Chlorfluazuron
What is Chlorfluazuron (71422-67-8)?The insecticide Chlorfluazuron is an organic compound with the molecular formula C20H9Cl3F5N3O3, Cas 71422-67-8。It is white crystal with vapor pressure <10nPa (20℃), solubility in water at 20℃ <0.01 mg/L, hexane <0.01, n-octanol 1, xylene 2.5, methanol 2.5, toluene 6.6, isopropyl alcohol 7, di Methyl chloride 22, acetone 55, cyclohexanone 110 (g/L, 20℃), stable under light and heat. Belongs to benzoylurea insect growth regulator. It is mainly gastric poisoning, has strong contact killing effect, has poor permeability and has no systemic effect.
The insecticide Chlorfluazuron is a benzoyl urea fluorinated nitrogen-heterocyclic insecticide with unique action mechanism, high efficiency, extremely low toxicity, and environmental friendliness. It can be used on vegetables, cotton, fruit trees, pine trees, etc. It mainly controls cabbage caterpillars, diamondback moths, cotton bollworms, apple and peach heartworms and pine caterpillars. The control effect is remarkable, especially for the control of vegetable pests. It will become a substitute for the highly toxic ones currently used. One of the main varieties of pesticides, it provides a new variety of pesticides for the production of green food.
Chlorfluazuron (71422-67-8) Physical and Chemical Properties
The pure product of the insecticide Chlorfluazuron is white or yellow-white odorless crystalline powder with a melting point of 226.5°C (decomposition). Hardly soluble in water, easily soluble in ketones, aromatic hydrocarbons and alcohols. Stable under light and heat, stable under neutral and weakly acidic conditions, and easily decomposed when exposed to alkali.
Chlorfluazuron(71422-67-8) Properties
The pure product of the insecticide fluridonil is white, odorless crystals. m.p.232～233.5℃, relative density 1.4977 (20℃), vapor pressure <1×10-10Pa (20℃). Dissolved into: cyclohexanone 110g/L, acetone 52.1g/L, ethyl acetate 45.7g/L, dichloroethane 22g/L, toluene 6.5g/L, xylene 3g/L, methanol 2.5(2.2) g/L, ethanol 2.0g/L, n-octanol 1g/L, hexane 10mg/L, water 0.016mg/L. Stable when stored at room temperature and stable to light. The original drug is yellow-brown crystal with a melting point of 220~223.9℃.
Chlorfluazuron (71422-67-8) Toxicity
The acute oral LD50 in rats is 8500mg/kg, the mouse is 7000mg/kg, the acute dermal LD50 in rats is 1000mg/kg; the acute inhalation LC50 in rats is 1846mg/m3. It is non-irritating to rabbit eyes and skin. Guinea pig sensitization test was negative. The subacute oral ineffective dose in rats is 3 mg/kg per day, the subacute oral inactive dose in rabbits is 1000 mg/kg per day, and the chronic oral inactive dose in rats is 50 mg/kg. No teratogenic, carcinogenic or mutagenic effects were found. The LC50 of carp is 300mg/L (96h), which is safe for birds and bees, but sensitive to silkworms.
Chlorfluazuron (71422-67-8) mechanism of action
The insecticide flufluridon inhibits chitin synthesis, hinders the normal molting of insects, causes egg hatching, larval peeling and pupal development abnormalities, and blocks the emergence of adults.
Characteristics of Chlorfluazuron (71422-67-8)
The insecticide flufluridon is stomach toxic and contact poisonous. It has high efficacy, but slow action speed. It is highly active against Lepidoptera, Coleoptera, Orthoptera, Hymenoptera, Diptera, etc., but it is ineffective against aphids, leafhoppers and plant lice.
Chlorfluazuron (71422-67-8) Features
Chlorfluazuron is a low-toxicity insecticide of the insect growth regulator type. It is mainly gastric poisoning, has contact killing effect, and has no systemic effect. Its insecticidal mechanism mainly inhibits chitin synthesis, hinders the normal molting of insects, causes egg hatching, larval molting, and pupal development to become deformed, and the emergence of adults is blocked, ultimately leading to the death of the pests. The drug is highly effective, but the action is slow. The larvae will not die quickly after exposure to the drug, but their feeding activities are significantly weakened. The peak control effect is generally reached 5 to 7 days after the drug is administered. It has high insecticidal activity against a variety of lepidopteran pests as well as Orthoptera, Coleoptera, Hymenoptera, Diptera and other pests, but it is ineffective against aphids, mold planthoppers and other pests. It is suitable for the comprehensive management of pests that have developed resistance to organophosphorus, pyrethroids, carbamates and other pesticides.
The insecticide fluflufenuron is sometimes combined with profenofos, chlorpyrifos, malathion, triazophos, insecticide, Spodoptera litura nuclear polyhedrosis virus, beta-cypermethrin, emamectin benzoate, etc. Pesticide ingredients are mixed to produce compound pesticides.
The insecticide flufluridon has stomach poisoning and contact killing (inhibiting chitin synthesis) effects. It is highly effective against pests, but its effect is slow. The mechanism of action is to inhibit chitin synthesis, hinder the normal molting of insects, cause egg hatching, larval molting and pupal development to be deformed, and adult emergence to be hindered.
① Unique mechanism of action: Chlorfluazuron mainly inhibits the synthesis of chitin, hinders the normal peeling of insects, causes egg hatching, larval peeling and pupal development abnormalities, and blocks the emergence of adults, thus exerting its insecticidal effect.
② High efficiency: The general concentration of Chlorfluazuron is 12.5-50PPm, and a dosage of about 0.75-1.5 grams per mu (ai) can achieve good control effects.
③Low toxicity: The unique mechanism of action of this drug determines its low toxicity to humans and animals. The acute oral LD50 of the original drug in rats is >8500 mg/kg, and the toxicity is extremely low.
④ Environmentally friendly: The drug is harmless to fish, bees, and birds at the dosage used, and can effectively protect natural enemies.
⑤Long duration of effect: The drug has effects on eggs, larvae, and adults, and the duration of effect can reach more than 15 days.
Chlorfluazuron (71422-67-8) Applicable objects
The insecticide flufluridon is suitable for use on a variety of fruits and vegetables, and has a specific control effect on lepidopteran pests. At present, in the production of fruits and vegetables, it is mainly used to control: Diamondback moth, exigua exigua, cabbage caterpillar, Spodoptera exigua, Spodoptera litura, tobacco caterpillar, etc. in cruciferous vegetables, and cotton bollworm in solanaceous fruits and melon and fruit vegetables. , beet armyworm, tobacco caterpillar, Spodoptera litura, etc., pod borer, bean field borer of legumes and vegetables, etc.
Highly active against Lepidoptera, Coleoptera, Orthoptera, Hymenoptera, Diptera, etc., but ineffective against aphids, leafhoppers, and planthoppers.
1. To control cabbage caterpillars and diamondback moths, spray with 1000-4000 times of 5% EC during the 1st to 3rd instar larval stages. Appropriate adjustments can be made within the above concentration range according to the severity of the pest occurrence and the age of the pests.
2. To control eggplant ladybirds, potato ladybirds, Spodoptera litura, cutworms, etc., spray 2000-3000 times of 5% EC during the initial hatching period of the larvae.
3. To control pod borer, apply 1,000 to 2,000 times of the solution once during the flowering period of the crop and once during the egg-laying period of the pest.
Chlorfluazuron (71422-67-8) usage technology
Prevention and control of lepidopteran pests such as diamondback moth, exigua exigua, cabbage caterpillar, Spodoptera exigua, tobacco caterpillar and other lepidopteran pests in cruciferous vegetables
Spray the pesticide evenly from the peak of egg hatching to the young larvae stage, once every 7 days. Pay special attention to spraying the back of the leaves so that the spray is evenly applied on the back of the leaves. When the pests are more severe, it is best to mix it with a quick-acting insecticide. Generally, 5% EC or 50 g/L EC 80-100 ml, or 50% EC 8-10 ml is used per mu, and 30-60 kg of water is sprayed evenly; or 5% EC or 50 g/L EC 500-100 ml is used. 700 times liquid, or 5000-7000 times liquid of 50% emulsifiable concentrate and spray evenly.
Prevention and control of lepidopteran pests such as cotton bollworm, beet armyworm, tobacco caterpillar, and Spodoptera litura on solanaceous fruits and melon and fruit vegetables.
Start spraying evenly from the peak hatching period of pest eggs to before the larvae cause damage or at the early stage of the young larvae, once every 7 days. When the pests are more severe, it is best to mix it with a quick-acting insecticide. Generally, 5% EC or 50 g/L EC 400-600 times liquid is used, or 50% EC 4000-6000 times liquid is sprayed evenly.
Prevention and control of lepidopteran pests such as bean borer and bean field borer on legumes and vegetables
Spray during the peak hatching period of pest eggs and before the larvae bore and cause damage. Focus on spraying flower buds, tender pods and other parts. Spraying in the morning and evening will have better results. Generally, 5% EC or 50 g/L EC 600-800 times liquid is used, or 50% EC 6000-8000 times liquid spray is used.
Chlorfluazuron (71422-67-8) uses
The insecticide flufluridon is a benzoylurea insect growth regulator. It is mainly gastric poisoning, has strong contact killing effect, has poor permeability and has no systemic effect. The insecticidal mechanism is to inhibit the formation of chitin, hinder the normal molting of pests, hinder egg hatching, larval molting, kidney development abnormalities, and adult emergence and egg laying, thereby achieving the insecticidal effect. This agent has high activity, slow action rate, and long half-life in the larvae.
The insecticide flufluridon is a broad-spectrum insecticide, effective against a variety of Lepidopteran pests as well as Diptera, Orthoptera, and Hymenoptera pests. It is effective against insects on vegetables and can also be used to control various pests on cabbage, cotton, tea trees and fruit trees. For the 1st to 2nd instar larvae of vegetables such as Diamondback moth, Spodoptera exigua, Spodoptera litura, and caterpillar cabbage, spray 2000-4000 times of 5% EC during the peak growth period. The effect lasts for 10-14 days, and the insecticidal effect reaches 90%. above. For example, during the peak hatching period of cotton bollworm eggs, spray with 1000-2000 times of 5% EC, and the insecticidal effect will be 80%-90% after 7 days. When applied at the recommended concentration, it will not cause any harm to crops and is safe for bees and non-target beneficial insects.
The insecticide flufluridon is a benzoylurea chitin inhibitor. It has high insecticidal activity and is a highly efficient, low-toxic, environmentally compatible pesticide. It will become one of the main varieties to replace the currently used highly toxic pesticides.
The insecticide flufluuron is mainly used for the control of pests such as cabbage caterpillar, diamondback moth, bean borer, and Spodoptera litura on vegetables, as well as the control of cotton bollworm, pink bollworm, etc. It also has good control effects on fruit tree pests such as orange leafminer and apple and peach heartworm. The control effect is particularly significant against pests that have developed resistance to other insecticides such as organophosphates, carbamates, and pyrethroids. The promotion and application of vegetable pest control will greatly improve the quality of vegetable products, promote the development of efficient and high-quality agriculture, and serve as an alternative to current highly toxic pesticides.
Chlorfluazuron (71422-67-8) prevention and control
(1) Cotton pests: It can control cotton bollworm and pink bollworm. During the egg hatching period, spray 60-140 ml of 5% EC per acre, add 70-80 kg of water and spray.
(2) Vegetable pests: cabbage caterpillar, diamondback moth, beet armyworm, Spodoptera exigua, Spodoptera exigua, cabbage exigua, cutworm, etc. Apply this drug during the initial hatching stage of the larvae, and spray 5 times per acre. % EC 40-80 ml, add 40-60 kg of water and spray.
To control bean borer, spray with 5% EC 1000-2000 times during the flowering period of pinto beans and kidney beans and the egg-laying period of bean borer.
To prevent and control leek maggots, use 100-200 ml of 5% EC per acre of land, add 150 kg of water, and dig ditches to irrigate the roots. The effect lasts up to 90 days.
(3) Fruit tree pests: It can control citrus leaf miner, litchi exigua, peach heartworm, pear heartworm, poisonous moth, boat caterpillar, jujube thorn moth, etc. Spray with 5% EC 1500-2000 times liquid.
(4) Tea tree pests: To control tea loopers and tea caterpillars, during the egg hatching period, use 40-75 ml of 5% EC per mu, add 50-75 kg of water (1000-2000 times liquid), and spray the canopy. This medicine is toxic to silkworms, fish and shellfish, so be careful when using it.
Chlorfluazuron (71422-67-8) production method
Preparation of 2,6-difluorobenzonitrile 2,6-dichlorobenzonitrile can be prepared from 2,6-dichlorotoluene through ammoxidation method in one step. Using 2,6-dichlorobenzonitrile as raw material, potassium fluoride as fluorinating agent, DMF, DMSO or sulfolane as solvent, the reaction temperature is 200~250℃. The synthesis method of 2,6-difluorobenzonitrile has the following improvements.
① Synthesis using quaternary ammonium salts, quaternary phosphorus salts, crown ethers, polyethers, etc. as phase transfer catalysts. If polyether is used as the catalyst, the reaction temperature is 210 to 230°C, the time is 8 to 10 hours, and the yield is 86%.
② Due to the influence of the strong electron-withdrawing group -CN, the halogen in the ortho position of the aryl group will be lost under general fluorination conditions. After adding the stabilizer m-dinitrobenzene, the above phenomenon is obviously suppressed, thereby increasing the yield. .
③The above reaction adopts a segmented insulation method (170℃, 0.5h, 175℃, 2h, 220℃, 4h), and the yield reaches 95.6%.
④ Increase the surface area of KF and use spray drying method to produce ultra-fine anhydrous KF with a yield of up to 80%. The preparation of 2,6-difluorobenzamide uses sulfuric acid as a catalyst, and a nucleophilic addition reaction occurs between 2,6-difluorobenzonitrile and water to prepare the corresponding sulfate. Neutralize to pH 6 with alkali to obtain 2,6-difluorobenzamide. The synthesis of fluoride is in dichloroethane solvent, 2,6-difluorobenzamide reacts with phosgene at 50°C for 1 hour to prepare 2,6-difluorobenzoyl isocyanate, which is then reacted with 4- (3-Chloro-5-trifluoromethylpyridin-2-oxy)-3,5-dichloroaniline can be used to prepare fluoride.
Chlorfluazuron (71422-67-8) compound
(1) 5% high chloride·fluridinuride emulsifiable concentrate: This product is a pyrethroid and benzoyl urea pesticide, which has contact and stomach poisoning effects on insects. Its mechanism of action inhibits chitin synthesis in diamondback moths and disrupts insect nerves. The normal physiology of the insect causes excitement, spasm, and paralysis, eventually leading to the death of the insect. Mainly used to control cruciferous vegetable diamondback moth and beet armyworm. Apply the pesticide from the egg hatching period to the young larvae of diamondback moth and exigua exigua. Use 50 to 80 ml per acre, mix with water and spray. Pay attention to spray evenly and use it in the evening. The prevention effect reached 97.9% after 3 days.
(2) 15% emamectin·fluridinuride water-dispersible granules: This product has gastric toxicity and a certain contact killing effect. By inhibiting the synthesis of insect epidermal chitin, the larvae cannot molt normally and die. They all have the characteristics of broad insecticidal spectrum, long duration of effect, no resistance, low toxicity and environmental protection, low toxicity to humans, livestock, poultry, fish, shrimp and aquatic animals, and natural enemies of bees and insects. They mainly control cotton bollworm, diamondback moth, and beetroot. Moths, Spodoptera litura, bean borer, rice leaf roller, cutworm, ground maggot, ginger borer, peach heartworm, suitable for the production of pollution-free fruits and vegetables. Apply pesticide at the peak period of the young larvae of the pest, 15-25 grams per acre, mix with water and spray evenly, with an interval of 7-10 days.
(3) 5% Avermectin·Chlorfluazuron EC: This product is a compound of Avermectin and Chlorfluazuron. It has contact and gastric poisoning and certain fumigation effects. It has the characteristics of broad spectrum, long term effect on crops and stable efficacy, and can be used to control various pests such as cabbage caterpillar, diamondback moth, leaf miner, cotton bollworm, yellow psyllid, red spider mite, leaf miner and other pests. When spraying at the young larval stage, use 10-20 ml per acre. The control effect can reach more than 95%, and the effect lasts for 7 to 10 days.
(4) 5% Chlorfluazuron EC: To control leek maggots, green onions and garlic root maggots, adopt the toxic soil method, that is, use 200~300 ml of 5% Chlorfluazuron EC per mu (667 square meters), mixed with 30 kg of fine sandy soil Stir evenly, spread leeks, garlic, and green onions evenly on the soil surface along the ridges, and then water along the ridges. The agent penetrates into the bulbs and can produce sustained control effects on leek maggots and root maggots, and is effective against both the current and second generation larvae. inhibition.
Chlorfluazuron (71422-67-8) Precautions
When spraying, the liquid must wet all the branches and leaves in order to be effective. The appropriate period is about 3 days earlier than that of ordinary organophosphorus and pyrethroid insecticides. Spray at the low larval stage, when boring pests are laying eggs. The pesticide application effect is good during the peak period.
1. This agent is an agent that hinders the molting of larvae and causes their death. It takes 3-5 days from application to the death of the pests. It must be used in the early larval stage.
2. This agent has no systemic conduction effect and must be applied evenly and thoughtfully.
3. This product is toxic to bees, fish and other aquatic organisms, and silkworms. During the application period, the impact on surrounding bee colonies should be avoided. It is prohibited during the flowering period of nectar crops, silkworm rooms and mulberry gardens. Apply pesticides away from aquaculture areas, and it is prohibited to wash pesticide application equipment in rivers, ponds and other water bodies.
4. Keep away from pregnant and lactating women.
5. Cotton and cabbage should not be used more than 3 times per season, and citrus should not be used more than 2 times per season. The safety interval is 21 days for cotton and citrus, and 7 days for cabbage.
6. Please read the label carefully before use.
7. Cannot be mixed with alkaline agents.
8. If 0.03% silicone or 0.1% washing powder is added to the medicinal solution, the efficacy can be significantly improved.
Chlorfluazuron (71422-67-8) insecticide price
Under normal circumstances, the price of the pesticide flufluridon will be affected by raw materials, market environment, research and development costs, etc. If you would like to know the latest price of the pesticide fluzuron you need, please contact us to initiate an inquiry.
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Chlorfluazuron (71422-67-8) Insecticide Suppliers
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