Carbosulfan Agricultural Insecticides
What is Carbosulfan?
Carbosulfan is a broad-spectrum systemic carbamate insecticide closely related to its main metabolite - carbofuran.Cas 55285-14-8 Carbosulfan delivers control of a wide range of soil-dwelling and foliar insect pests.It has low water solubility, is non-volatile and, based on its chemical properties, does not typically leach into groundwater. It generally does not persist in soil or water systems. It is moderately toxic to mammals, is a skin sensitizer and a cholinesterase inhibitor. It exhibits moderate to high ecotoxicity to most species.
Carbosulfan is a carbamate organic compound.At normal conditions, it is brown viscous liquid. It is not very stable; it decomposes slowly at room temperature. Its solubility in water is low but it is miscible with xylene, hexane, chloroform, dichloromethane, methanol and acetone. Carbosulfan is used as an insecticide. The European Union banned use of carbosulfan in 2007.
Its oral LD50 for rats is 90 to 250 mg/kg bw, inhalation LC50 is 0.61 mg/L. Carbosulfan is only slightly absorbed through skin (LD50 >2000 mg/kg for rabbits). The mechanism of toxicity is based on reversible inhibition of acetylcholinesterase (as for carbamates generally).Carbosulfan has very low maximum residue limits for use in the EU and UK examples of this can be seen in apples and oranges, where it is 0.05 mg/kg.
Is carbofuran a pesticide or insecticide?
Carbofuran is a systemic, broad spectrum N-methyl carbamate insecticide and nematicide registered for control of soil and foliar pests on a variety of field, fruit, and vegetable crops. There are no residential uses. Nearly 1 million pounds of carbofuran are applied annually. Carbofuran is a restricted use pesticide.
What is the mode of action of Carbosulfan insecticide?
Carbosulfan Biochemistry Cholinesterase inhibitor; activity is due to in vivo cleavage of the N-S bond, resulting in conversion to carbofuran. Mode of action Systemic insecticide with contact and stomach action.
Insecticide Carbosulfan price
Normally, the price of the pesticide and Insecticide Carbosulfan is affected by raw materials, market environment, R&D costs, etc. If you want to know the latest priceof the pesticide and Insecticide Carbosulfan you need, please contact us to initiate an inquiry.
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Insecticide Carbosulfan supplier
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What is carbosulfan insecticide used for?
Carbosulfan is a broad-spectrum carbamate pesticide used to control insects, mites and nematodes by soil, foliar and seed treatment applications, mainly on potatoes, sugar beet, rice, maize and citrus. Carbofuran is the main metabolite of carbosulfan in plants and is itself a pesticide.
Carbofuran is a systemic, broad spectrum N-methyl carbamate insecticide and nematicide registered for control of soil and foliar pests on a variety of field, fruit, and vegetable crops. There are no residential uses.
Nearly 1 million pounds of carbofuran are applied annually.
Carbofuran is a restricted use pesticide.
Carbosulfan was evaluated for residues under the Periodic Review Programme by the JMPR in 1997. The present evaluation of carbosulfan includes estimates for carbofuran resulting from the use of carbosulfan. The current definition of the carbosulfan residue for compliance with MRLs and for dietary risk assessment is "carbosulfan".
The carbofuran residue is defined as carbofuran + 3-hydroxycarbofuran for compliance with MRLs and carbofuran + 3-hydroxycarbofuran + conjugated 3-hydroxycarbofuran for dietary risk assessment.
Carbosulfan application
Carbosulfan is an insecticide for control of soil dwelling and foliar pests.
Carbosulfan is known as a systemic contact and stomach insecticide and nematicide for the control of certain pests on cotton, maize and grapevines.
Carbosulfan usage has increased in recent years because it is one of the few insecticides effective on soybean aphids.
Carbonsulfan and carbofuran are not same material, and carbonsulfan has lower toxicity comparing carbofuran, it is like second generation of carbofuran.
Cholinesterase inhibitor; activity is due to in vivo cleavage of the N-S bond, resulting in conversion to carbofuran.
Control of a wide range of soil-dwelling and foliar insect pests. Examples of uses include control of millipedes, springtails, symphylids, wireworms, pygmy mangold beetles, frit flies, white grubs, aphids, caterpillars, flea beetles, Colorado beetles, stem borers, leafhoppers, planthoppers, codling moth, scales and free-living nematodes. The product is used in a wide range of crops, e.g. cotton, sugar beet, potatoes, rice, top fruit, citrus, maize, vegetables, sugar cane and coffee.
Carbosulfan characteristic
Carbosulfan lethal strong, quick effect, with gastric toxicity and the effect of the contact.It is characterized by fat solubility, good absorption, strong permeability, rapid action, low residue, long residual effect, safe use, etc. It is effective for adults and larvae, and harmless to crops.It can control pests of citrus and other fruits and vegetables, corn, cotton, rice, sugar cane and other economic crops, especially the aphid control effect is excellent.Such as: citrus rust ticks, aphids, potential leaf moths, scale insects, cotton aphids, cotton bollworms, cotton leafhoppers, fruit aphids, vegetable aphids, thrips, cane borer, corn aphids, bugs, tea tree aphids, small green leafhoppers, rice thrips, borers, leafhoppers, planthoppers, wheat aphids, etc.
Carbosulfan Instructions
This product is a derivative of carbofuran, which has the same insecticidal activity as carbofuran .But its toxicity is much lower than carbofuran, a stomach insecticide .It can be metabolized into carbofuran in the organism and then play its effect to kill the insect. It has excellent control effect on the potato green peach aphid, black beetle, high dyed blind fly, cutworm and other insects. In addition, it can also better control cotton spider mite, billbug, tribolium confusum and spodoptera moth etc..
Carbamate insecticides, acaridants and nematides with high absorbability and broad-spectrum properties. It is a low toxic variety of Carbosulfan for the control of citrus, fruit trees, cotton and rice crops of aphids, mites, wireworm, beet and potato beetles, a hidden food tea leafhopper, Grapholitha molesta, codling moth and other pests. The administration concentration is 5mg/L and the effective component is 6.8 ~ 15g /100m2.
Low toxic insecticides with internal absorbability and broad-spectrum
For the control of rust ticks, aphids, thrips, leafhoppers and other more than 10 kinds of pests on the fruit trees, cotton, vegetables, grain and other crops.
Carbosulfan Chemical properties
Brown sticky liquid. B.p. is124 ~ 128 ℃ (114 ℃). The flash point is 115~1,117℃, and the vapor pressure is 0.041 x 10-3Pa. The relative density is 1.056 (20℃). It can dissolve with acetone, ethanol and xylene, and the solubility in water is 0.3mg/L. The distribution coefficient is 157 (pH value is 7.05).
It has a fast decomposition in water, easily decomposed into carbofuran with pH<7. In the sun, when the 5 g/mL of Carbosulfan is in buffer solution with pH equaling to 7, the half-life period is 1.4d and 4 ~ 8d in distilled water.
Carbosulfan Preparation Method
Preparation method 1:
Preparation of two n-butanamine sulphide Add two n-butyl amine and petroleum ether (60~90℃ ), mixing and cooling to 0℃ . Then slowly drip disulfur dichloride and maintain the temperature at 0~10 ℃. Afterwards, the reaction will be maintained at a constant temperature. The proportioning of the di-n-butylamine, disulfur dichloride and sulfuric chloride is 1:0.6:0.55(mol). The yield is 88%.
The synthesis of carbosulfan Two n-butanamine sulphur chloride reacts with carbosulfan with the ratio of 1:1. The reaction process is added with a proper amount of alkaline solution, and the reaction temperature is 10~20 ℃. The reaction time period is 2h. Add water and mix it for 10 minutes after the reaction. Filter it and the unreacted is carbosulfan which can be reused. The filtrate is stratified and the oil layer is decompressed and dissolving, and the yield is 90%.
Preparation method 2:
The synthesis of the intermediates hydroxyl compounds can be take the carbosulfan as reference. There are also literature reporting that starting from cyclohexanone and isobutyrate, five steps will be able to get it synthesized through condensation, chlorination, aromatization, hydrolysis and closed loop reaction. It is characterized by the synthesis of non aromatic compounds and is a highly selective synthesis route.
Carbosulfan Reactivity Profile
Carbosulfan is a thiocarbamate. Flammable gases are generated by the combination of thiocarbamates and dithiocarbamates with aldehydes, nitrides, and hydrides. Thiocarbamates and dithiocarbamates are incompatible with acids, peroxides, and acid halides.
Carbosulfan Potential Exposure
Carbosulfan is a carbamate insecticide and a low toxic derivative from cabofuran. It is a broad spectrum insecticide, nematicide, miticide, effective against pests and mites. It is used to protect alfalfa, apple, citrus, corn, deciduous fruit, potato, rice, sorghum, soybean, sugar beets, sugarcane, and other vegetable, field, tree and orchard crops. It is used for seed treatments
Carbosulfan Metabolic pathway
Carbosulfan is an N-sulfenyl-N-methylcarbamate which is effectively a pro-insecticide of carbofuran. The latter is formed in vivo by the biochemical or chemical thiolysis of carbosulfan. N-S Bond cleavage, oxidation, conjugation and hydrolysis are the main metabolic routes for carbosulfan in plants and animals. Carbosulfan is degraded via carbofuran in soil. In plants, carbosulfan is metabolised via carbofuran to 3-hydroxycarbofuran (PM).
Carbosulfan Metabolism
Itsmetabolic patterns are similar to those of carbofuran. In rats, it rapidly undergoes hydrolytic and oxidative processes followed by conjugation. It is not persistent in soils, with DT50 ca. 2–5 days, and it was rapidly degraded to carbofuran in a sandy loam soil (4). Carbofuran was subsequently hydrolyzed at the carbamate ester group to form the phenol carbofuran or oxidized at the 3- position. Biscarbofuran disulfide and minor products were also detected. Carbofuran was also formed in soils by nonbiological degradation processes.