Chlorfluazuron Insecticide
What is Chlorfluazuron?Chlorfluazuron is a benzoylurea insecticide, an organochlorine insecticide, an organofluorine insecticide and a dichlorobenzene.Cas 71422-67-8Chlorfluazuron is a benzoylurea fluorinated nitrogen heterocyclic pesticide with unique mechanism of action, high efficiency, low toxicity and being environmentally friendly. It can be used in vegetables, cotton, fruit trees and pine trees. It is mainly used for controlling Pieris rapae, Plutella xylostella, Helicoverpa armigera, apple peach moth, and pine caterpillars. Its prevention and cure effect is remarkable, especially for the control of vegetable pests; it is expected that it is one of the main varieties that replace the current highly toxic pesticide, providing a new pesticide variety for the production of green food.
Chlorfluazuron Mode of Action
Chlorfluazuron, which acts as an anti-molting agent, inhibits biosynthesis of chitin in the insect cuticle, which causes loss of cuticle elasticity and rmness, and results in abortive molting.
Chlorfluazuron Characterisitics
Chlorfluazuron It is of gastric poisoning, contact kill (inhibition of chitin synthesis) effect with high efficacy against pests, but the efficacy is slow. The mechanism of action is through inhibition of chitin synthesis, hindering insect normal molting, egg hatching, larvae molting and pupal developmental deformity and block of adult feather.
Chitin synthesis inhibitor Interrupts insect molting and growth Active against larval stages of a broad spectrum of Lepidopteran insects Long residual activity Active against certain Coleoptera, Hemiptera,Thysanoptera and Blattodea Stomach toxin - active through ingestion Effective at low rates (10-100 g a.i./ha) Easy to use (liquid formulation)Safe to bene cial insects.
Insecticide Chlorfluazuron price
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Insecticide Chlorfluazuron supplier
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What is Chlorfluazuron used for?
Chlorfluazuron is an insect growth regulator that inhibits chitin synthesis and provides good control of various pest insects, especially Lepidoptera, at a low dose rate. Chlorfluazuron has very little negative impact on natural enemies and pollinating insects, and can be used in integrated pest management programs.
Chlorfluazuron Application
Chlorfluazuron Benzoyl urea insect growth regulator. Major effect is through stomach poisoning, coupled with strong contact action. Its permeability is poor with no endosuction effect.
Insecticidal mechanism is through inhibiting the formation of chitin, hindering the normal molting, causing egg hatching, larvae molting, kidney malformations, adult emergence and obstruction of eggs, so as to achieve the effect of insecticide. It has high activity and slow acting speed, and has a longer half-life in larvae. The agent is a broad-spectrum insecticide and is effective against various Lepidoptera pests and Diptera, Orthoptera and Hymenoptera. It is quite effective on insects on the vegetables, can also be used to control a variety of pests on cabbage, cotton, tea trees and fruit trees.
Chlorfluazuron Control of Lepidoptera such as Helicoverpa, Spodoptera and Pseudoplusia on soybean; and Plutella, Spodoptera and thrips on vegetables;Adoxophyes, Ascotis on tea and fruit trees. Also used on potatoes,ornamentals and turf. Application rate : 10-100 g a.i./ha
Chlorfluazuron is one of the leasing compoundsin the benzoylphenylurea IGR insecticides. for mainly controlling Lepidoptera on cotton, bean, vegetables and fruit trees, etc.Chlorfluazuron is an insect growth regulator inhibiting chitin synthesis and can give a good control of various pest insects, especially Lepidoptera, at low dose rate.Chlorfluazuron has very little negative impact on natural enemies and pollinator insects,m and can be used in integrated pest management programs.
Chlorfluazuron Controlling objects
Chlorfluazuron It is of high activity against Lepidoptera, Coleoptera, Orthoptera, Hymenoptera and Diptera with no effects on aphids, leafhoppers and planthoppers.
Control Pieris rapae and diamondback moth; during 1 to 3 instar larvae stage, apply 1 000 ~ 4 000 times 5% EC times for spray. Make appropriate adjustment in the above concentration range according to the severity of the pest and the size of insect instar.
Control Eucalyptus ladybugs, potato ladybugs, Spodoptera litura and cutworm; during the larval hatch stage, use 2000~3000 times 5% EC for spray.
Prevention and control of pod borer, use 1 000 ~ 2 000 times liquid to administrate once in both the crop flowering stage and pest egg stage.
Chlorfluazuron use
Chlorfluazuron Its application period is generally 3 days earlier than normal organophosphate, pyrethrins insecticide; in the best case, spray during the young larvae stage; for boring pests, it should be applied during the peak stage of egging.
No suction conduction effect; the application must be uniform and thoughtful.
Avoid using it in the mulberry fields, fish ponds and other places.
For cotton and cabbage area, do not use more than 3 times for crops per season; for citrus, do not use more than 2 times. The safe interval is 21 days for cotton and citrus and 7 days for cabbage.
Chlorfluazuron is benzoyl(pyridiyloxyphenyl)urea based pesticide that acts as a chitin synthesis inhibitor. Chlorfluazuron is commonly used in agriculture as an insect growth regulator for controlling the major insect pests in crops.
Chlorfluazuron is used for the control of Heliothis, Spodoptera, Bemisia tabaci and other chewing insects on cotton, and Plutella and Thrips on vegetables. It is also used on fruit, potatoes, ornamentals and tea.
Chlorfluazuron Chemical properties
Pure product appears as white or yellowish white tasteless crystalline powder with a melting point of 226.5 ℃ (decomposition). It is hard to be dissolved in water, being easily soluble in ketones, aromatic hydrocarbons and alcohols. Stable under light and heat, stable under neutral and weak acid conditions; it is easily subject to decomposition to alkali treatment.
Pure product appears as white odor-free crystal. m. p. 232-233.5 ° C, relative density 1.4977 (20 ° C), vapor pressure <1 x 10-10 Pa (20 ° C). Solubility: cyclohexanone 110g / L, acetone 52.1g / L, ethyl acetate 45.7g / L, ethylene dichloride 22g / L, toluene 6.5g / L, xylene 3g / L, methanol 2.5 (2.2) g / L, ethanol 2.0 g / L, n-octanol 1 g / L, hexane 10 mg / L and water 0.016 mg / L. Stable at room temperature; stable to light. The proto-drug is yellow-brown crystal with a melting point of220 ~ 223.9 ℃.
Chlorfluazuron Toxicity
Rats acute oral LD50 8500mg / kg, mice 7000mg / kg, rat-acute percutaneous LD50 1000mg / kg; rat-acute inhalation LC50 1846mg / m3. No irritation effect on rabbit eyes and skin. Guinea pig sensitization test result is negative. The sub-acute oral no-effect dose for rat is 3mg / kg; rabbits subcutaneous sub-acute no-effect daily dose of rabbit is 1000mg / kg; chronic oral no-effect dose for rat is 50mg / kg. No teratogenic, carcinogenic, mutagenic effects were found. Carp LC50 300mg / L (96h); safe for birds and bees; sensitive to silkworms.
Chlorfluazuron Synthesis
Have 2, 6-dichloro-4-aminophenol and 2, 3-dichloro-5-trifluoromethylpyridine subject to etherification to give 3, 5-dichloro-4- (3- -trifluoromethyl-2-pyridyloxy) aniline, followed by reaction with 2, 6-difluorobenzoyl isocyanate (the reaction product of 2, 6-difluorobenzamide and solid phosgene) to obtain the target product Chlorfluazuron through condensation reaction; confirm its structure at the total yield of 95%.
Synthesis of 1, 3, 5-dichloro-4- (3-chloro-5-trifluoromethyl-2-pyridyloxy) aniline 18.2g (0.10 mol) of 2,6-dichloro-4-aminophenol, 21.6 g (0.10 mol) of 2,3- dichloro-5-trifluoromethylpyridine Potassium and 0.5 g of catalyst were dissolved in 120 mL of DMF and reacted at 110-115 ° C; apply chromatography monitoring, when the raw material 2,3-dichloro-5-trifluoromethylpyridine has a content ≤ 0.5%, stop the reaction for about 6h. After the completion of the reaction, the residue was removed by filtration and the solvent was removed under reduced pressure. The residue was further extracted with 3 × 100 mL of dichloroethane, washed with 3 × 150 mL of water until neutral and dried by anhydrous magnesium sulfate overnight to give the dichloroethane solution of 3,5-dichloro-4- (3-chloro-5-trifluoromethyl-2-pyridyloxy) aniline .
Synthesis of 2, 2, 6-difluorobenzoyl isocyanate
15.7 g (0.10 mol) of 2, 6-difluorobenzamide was dissolved in 150 mL of dichloroethane and 15.0 g (0.05 mol) of solid phosgene was added at -5 ° C. After holding for 1 hour, the mixture was heated to reflux 5h; the exhaust gas was absorbed by 5% sodium hydroxide solution. Apply chromatographic monitoring, when 2,6 - difluorobenzamide content ≤ 0.5%, cooled to room temperature for stand-by.
Synthesis of chlorfluazuron.
The dichloroethane solution of 3,5-dichloro-4- (3-chloro-5-trifluoromethyl-2-pyridyloxy) aniline was slowly added dropwise at 80 to 85 ?C to the dichloroethane solution of 2,6-difluorobenzoyl isocyanate; the dropwise addition time is controlled at about 30min; incubate for 2h, then apply sampling control; when the etherate content ≤ 0.5%, apply atmospheric recovery of the solvent dichloroethane, filtered, and dried to give 47.0 g of off-white to white chlorfluazuron product.