Do you know pyridaben, a pyridazinone insecticide and acaricide?
What is pyridaben?
The insecticide pyridaben is a broad-spectrum, contact acaricide, which can be used to control various plant-feeding mites. It has a good effect on the whole growth period of mites, that is, eggs, young mites, nymphs and adults, and it also has obvious quick-killing effect on adult mites in the moving stage. The medicine is not affected by temperature changes, and satisfactory results can be achieved no matter it is used in early spring or autumn.
The insecticide pyridaben belongs to the class of pyridazinone insecticides and acaricides. It has a strong contact type, but it has no fumigation, systemic and conduction effects. It mainly inhibits the synthesis of glutamate dehydrogenase in muscle tissue, nerve tissue and chromosome I of the electron transfer system, thereby exerting insecticidal and acaricidal effects.
Physicochemical properties of pyridaben
The insecticide pyridaben is a white crystal with a slight odor, with a melting point of 111-112 °C and a solubility in water of 0.012 mg/L at 20 °C.
Cas 96489-71-3
Preparation: 20% pyridaben wettable powder, 15% pyridaben emulsifiable concentrate.
The mechanism of action of pyridaben
Pyridaben belongs to the class of pyridazinone insecticides and acaricides. It has a strong contact type, but it has no fumigation, systemic and conduction effects. It mainly inhibits the synthesis of glutamate dehydrogenase in muscle tissue, nerve tissue and chromosome I of the electron transfer system, thereby exerting insecticidal and acaricidal effects. Control spectrum and method of use Pyridaben is a heterocyclic low-toxic insecticide and acaricide with a wide spectrum of acaricide, strong contact, no systemic, conduction and fumigation effects, and has obvious effects on all plant-eating pests. The control effect, such as panonychia, spider mites, synaptic mites, small claw mites, etc., and is effective in different growth stages of mites, such as in the egg stage, nymph stage, and adult mite stage, and in the adult mite stage The mobile period also has a preventive effect.
The insecticide pyridaben has obvious control effects on phytophagous harmful mites such as spider mites, panonychia, claw mites and gall mites, and is effective against eggs, nymphs, and adults. also works.
The insecticide pyridaben is suitable for citrus, apple, pear, hawthorn, cotton, tobacco, vegetables (except eggplant) and ornamental plants. If it is used to control citrus and apple spider mites, pears and hawthorns and other rust ticks, it can be applied during the occurrence period of harmful mites (in order to improve the control effect, it should be used when there are 2 to 3 heads per leaf on average), and 20% wettability Dilute powder or 15% emulsifiable oil with water to 50-70mg/L (2300-3000 times) and spray. The interval is 15 days, that is, the medication is stopped 15 days before harvest.
Pyridaben action characteristics
The insecticide pyridaben is a fast-acting broad-spectrum acaricide with moderate toxicity to mammals. Low toxicity to birds, high toxicity to fish, shrimp and bees. The agent has strong contact killing, no systemic, conduction and fumigation effects, and has good effects on various growth stages of spider mites (eggs, larvae, nymphs and adults); the control effect on rust mites is also good, quick-acting Good sex, long duration, generally up to 1-2 months.
1. Pyridaben Pyridaben is an insecticide mixed with Pyridaben and Pyridaben, which has contact killing effect, good quick-acting effect and long-lasting effect.
2. It has a poisonous effect on different stages of mites (eggs, larvae, nymphs, and adults) throughout the growth period, especially on the eggs of mites and pests in the moving stage.
3. No cross-resistance with commonly used acaricides, stable efficacy and not affected by temperature changes, safe for crops.
4. High activity, small particles, high suspension rate, good spreadability, strong adhesion and high efficacy.
What does pyridaben mainly kill?
1. Pyridaben is an organophosphorus acaricidal insecticide, which has contact killing effect, no systemic conduction and fumigation effect; it has strong lethality to eggs, juveniles, juveniles and adults of spider mites, and has strong lethality to rust mites. The control effect is also good; the drug effect is rapid, the duration of effect is as long as 30-50 days, and it is resistant to rain erosion; the acaricidal effect is not affected by temperature, and there is no cross-resistance with other chemicals. It is an ideal acaricidal pesticide during the occurrence of spider mites. .
2. Pyridaben is a low-toxic, broad-spectrum pollution-free pesticide; it is low-toxic to humans and livestock, but it is also harmful to crops; it is low-toxic to natural enemies, but highly toxic to fish; it has no phytotoxicity to deciduous fruit trees.
3. On fruit trees, it is mainly used to prevent and control Tetranychus hawthorn on apple and pear trees, Panonychus apple;
Uses of pyridaben
The insecticide pyridaben is a high-efficiency, broad-spectrum acaricide, non-systemic, and has obvious control effects on phytophagous pests such as spider mites, panonychia, small clawed mites and gall mites, etc. Both mites and adult mites are effective, and it is also effective for the migratory stage of adult mites. It is suitable for citrus, apple, pear, hawthorn, cotton, tobacco, vegetables (except eggplant) and ornamental plants. If it is used to control citrus and apple spider mites, pears and hawthorns and other rust ticks, it can be applied during the occurrence period of harmful mites (in order to improve the control effect, it is best to use it when there are 2 to 3 heads per leaf on average), and 20% Wettable powder or 15% emulsifiable concentrate is diluted with water to 50-70mg/L (2300-3000 times) and sprayed. The safe interval is 15 days, that is, the drug is stopped 15 days before harvest.
The insecticide pyridaben has a good knockdown effect on flea beetles, and the dosage of 3g per mu can kill flea beetles within 10 minutes.
How to use pyridaben
The insecticide pyridaben has been used for a long time, and the harmful mites have developed strong drug resistance. The compound use of insecticides and acaricides with different mechanisms of action can not only expand the scope of control, but also improve the efficacy and delay Resistance of pest mites.
(1) Avi·pyridaben: This formula is the classic formula of pyridaben, which makes up for the shortcoming of pyridaben without systemic absorption, has strong permeability, has contact killing, stomach poisoning and fumigation effects, and has good quick effect and long-lasting effect. Advantages such as long validity period. In the early stage of harmful mites, spray evenly with 10.5% Avi·Pyridaben EC 1000 times to treat red spiders, white spiders, rust ticks and other harmful mites on citrus, pear trees, apples and other fruit trees. All have good control effects.
(2) Tetramite · Pyridaben: The mixture of Tetrafen and Pyridaben has a good control effect on eggs, nymphs and adults, and is not sensitive to temperature. It can be used in spring, summer and autumn. It can be sprayed with 2000-2500 times of liquid in the initial stage of occurrence. It has a good effect on harmful mites such as spider mites and panonychia on fruit trees such as apples and citrus, and the effective period can reach 5060 days.
(3) Difuran · Pyridaben: Pyridaben and dinotefuran are used in combination, which has contact killing, stomach poisoning and systemic effects, and is an excellent formula for preventing and treating flea beetle. In the early stage of the emergence of cabbage flea beetle adults, use 30% difuran·pyridaben suspending agent 30-50 ml, mix with 30 kg of water and spray evenly, which has a good knockdown effect on red spider mite and flea beetle , The duration of validity can reach more than 20 days.
Pyridaben prevention and control objects and methods of use
The insecticide pyridaben is a heterocyclic low-toxic insecticide and acaricide with a wide spectrum of acaricide, strong contact, no systemic, conduction and fumigation effects, and has obvious control of all plant-eating pests Effects, such as panonychia, spider mites, synaptic mites, small clawed mites, etc., and are effective in different growth stages of mites, such as in the egg stage, nymph stage, and adult stage of mites, and in the movement of adult mites period also has a preventive effect.
The insecticide pyridaben is mainly used on fruit crops such as citrus, apple, pear, and hawthorn, and can also be used on vegetables (except eggplant), tobacco, tea, cotton, and ornamental plants. Pyridaben is widely used in the control of fruit tree pests and pest mites. However, it should be used under control in tea gardens for export.
It can be applied during the occurrence period of harmful mites (in order to improve the control effect, it is better to use when there are 2 to 3 heads per leaf on average), dilute 20% wettable powder or 15% emulsifiable oil to 50-70mg/L (2300-3000 times) spray. The safe interval is 15 days, that is, the drug is stopped 15 days before harvest. But the actual validity period should be more than 30 days.
1. Prevention and control of spider mites such as apples
To control apple red spider and hawthorn red spider, spray evenly once at the early flowering stage of apples and grapes, use 20% pyridaben wettable powder 3000-4500 times liquid or 15% pyridaben
Ling emulsifiable oil 3000~4000 times liquid (effective concentration 45-667 mg/kg) spray.
2. Control citrus spider mite
To prevent and control Panonychus citrus, according to different orientations of the tree, investigate a certain number of leaves, and apply once evenly when the local control index is reached, with 20% pyridaben wettable powder 3000-
4000 times liquid (effective concentration 50~60 mg) spray, the duration of effect can reach more than 30 days.
The use on other crops is based on combined experience and use indicators. In the case of uncertain use, the concentration is appropriately reduced and the dilution factor is increased.
Pyridaben control spectrum and usage method
The insecticide pyridaben is a heterocyclic low-toxic insecticide and acaricide with a wide spectrum of acaricide, strong contact, no systemic, conduction and fumigation effects, and has obvious control of all plant-eating pests Effects, such as panonychia, spider mites, synaptic mites, small clawed mites, etc., and are effective in different growth stages of mites, such as in the egg stage, nymph stage, and adult stage of mites, and in the movement of adult mites period also has a preventive effect. In my country, it is mainly used in fruit crops such as citrus, apple, pear, hawthorn, etc. It can also be used in vegetables (except eggplant), tobacco, tea, cotton, and ornamental plants. Pyridaben is widely used in the control of fruit tree pests and pest mites. However, it should be used under control in tea gardens for export. It can be applied during the occurrence period of harmful mites (in order to improve the control effect, it is best to use it when there are 2 to 3 heads per leaf on average), dilute 20% wettable powder or 15% emulsifiable oil to 50-70mg/L (2300-3000 times) spray. The safe interval is 15 days, that is, the drug is stopped 15 days before harvest. But the actual validity period should be more than 30 days.
Dosage of pyridaben
When the insecticide pyridaben is used to control rust ticks such as citrus and apple spider mites, pears and hawthorns, it can be applied during the occurrence of pest mites (in order to improve the control effect, use it when the average is 2 to 3 per leaf), Dilute 20% wettable powder or 15% emulsifiable concentrate with water to 50-70mg/L (2300-3000 times) and spray. The interval is 15 days, that is, the medication is stopped 15 days before harvest.
The insecticide pyridaben has a good knockdown effect on flea beetles, and the dosage of 3g per mu can kill flea beetles within 10 minutes.
Preparation or source of pyridaben
Add tert-butylhydrazine and furochloric acid into the reaction kettle, add solvent and react at 0-35°C for 2 hours, then add acetic acid and react for 4 hours, add water and react, let it stand for stratification, separate the lower layer of waste water, and add 5% Stir and wash with sodium hydroxide aqueous solution, separate the waste water and wash once with water, and remove the solvent from the organic layer to obtain brown crystals, which are pyridazinone. Add pyridazinone and solvent into the reaction kettle, add sodium hydrosulfide aqueous solution at 0-35°C, stir for 3 hours, then add p-tert-butylbenzyl chloride, stir for 4 hours, let stand to separate the water layer, and then Wash once with water, evaporate the solvent from the organic layer, and recrystallize with petroleum ether to obtain white or light yellow crystals, which is the original drug of pyridaben.
Tert-butylhydrazine (40%) 1.17 p-tert-butyl benzyl chloride (above 90°C) 0.80
Furochloric acid (above 95%) 0.94 Acetic acid (above 99%) 0.35
Sodium Hydrosulfide (70%) 0.51 Liquid Soda (30%) 1.0
Production method of pyridaben
Insecticide pyridaben preparation method Preparation of p-tert-butyl benzyl mercaptan In the presence of azobisisobutyronitrile, p-tert-butyltoluene was chlorinated with chlorine at 68-72°C for 6 hours to obtain p-tert-butyl Benzyl chloride; then the refined p-tert-butylbenzyl chloride is used as a solvent in toluene, and in the presence of tetrabutylammonium bromide and acetic acid, 23% sodium hydrosulfide aqueous solution is added dropwise, and the reaction is continued at 50°C for 30 minutes after the dropwise completion. After post-treatment, p-tert-butylbenzylmercaptan was obtained with a yield of 92%. Preparation of 2-tert-butyl-4,5-dichloro-3-(2H)-pyridazinone Mix furfural with concentrated hydrochloric acid and chlorinate with chlorine gas at 90-100°C to obtain furochloric acid with a yield of 87% ;React hydrazine hydrochloride and tert-butyl alcohol at 82-105°C to obtain tert-butylhydrazine hydrochloride, with a yield of 97%; then dissolve tert-butylhydrazine hydrochloride in 5% NaOH solution, Prolong the reaction of tetrahydrofuran furochlorate solution for 30 minutes, then raise the temperature to 10-15°C and react for 30 minutes to obtain tert-butyl hydrazone furochlorate with a yield of 87%; 35～45℃, react for 4 hours, condense and cyclize to generate 2-tert-butyl-4,5-dichloro-3(2H)-pyridazinone, the yield is 98%. Synthesis of pyridaben: 2-tert-butyl-4,5-dihydro-3(2H)-pyridazinone and p-tert-butylbenzylmercaptan were used as solvent, and sodium methoxide methanol solution was added at 0°C , stirred and reacted at 10-15°C for 1 hour, after post-treatment, pyridaben was obtained, m.p.111-112°C, yield 96%.
Other information about pyridaben
Stability: Stable for 90 days at 50°C; stable in organic solvents at pH 4, 7, 9; unstable to light, but the EC can be stable for more than 2 years under normal storage conditions.
When mixed with other medicines, a community test should be done first, and the dosage should be appropriate. If it hurts the skin, take off your clothes immediately and wash it with soapy water; if it hurts the eyes, wash it with water; if it is inhaled and poisoned, it should be sent to fresh air If necessary, loosen the button of the clothes to let it breathe freely, and send it to the hospital if necessary.
Packaging and storage
20% wettable powder is packed in aluminum foil plastic bags, each bag has a net weight of 100g; 15% emulsifiable concentrate is packed in polyester bottles, each bottle has a net weight of 250ml; it should be sealed and stored in the original container in a cool, dry, and ventilated place, and should not be mixed with food or feed remix.
Pyridaben toxicity
The acute oral LD50 of male rats is 1350mg/kg, the acute oral LD50 of female rats is 820mg/kg, and the acute percutaneous LD50 of rats and rabbits is greater than 2000mg/kg. It has no stimulating effect on rabbit skin and eyes, and has no effect on guinea pig skin. sensitivity. In the air, the LC50 of male rats inhaled is 066mg/L, and the LC50 of female rats is 062mg/L. Others are not mutagenic in the chromosome aberration test (Chinese hamster) and micronucleus test (mice). Not mutagenic in Ames or DNA repair assays.
Low toxicity insecticide, highly toxic to fish and other aquatic organisms.
Precautions for using pyridaben
1. This agent cannot be mixed with Bordeaux mixture.
2. This agent has a contact effect, and the front and back sides of the leaves should be sprayed evenly when spraying.
3. It is best to use this agent only once to delay the development of drug resistance.
4. The interval between use on apple trees is 14 days, and the crops in each season are used twice more.
5. Do not mix with alkaline pesticides and other substances.
6. When using this product, you should wear protective clothing and gloves, and take protective measures to avoid inhaling the liquid medicine. Do not eat or drink during application. Wash your hands, face and other exposed parts in time after application.
7. It is poisonous to bees, fish and other aquatic organisms, and silkworms. During the application period, the impact on the surrounding bee colonies should be avoided, and it is forbidden to be near the flowering period of honey crops, silkworm rooms and mulberry gardens. Apply pesticides away from aquaculture areas, and it is forbidden to wash pesticide application equipment in rivers and other water bodies.
8. It is recommended to use in rotation with other acaricides with different mechanisms of action to delay the development of resistance.
9. People with sensitive constitutions, pregnant women and breastfeeding women should avoid contact with this product.
The price of the insecticide pyridaben
Usually, the price of the pesticide pyridaben will be affected by raw materials, market environment, research and development costs, etc. If you want to know the latest price of the pesticide pyridaben you need, please contact us to initiate an inquiry.
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