High efficiency broad spectrum insecticide tebufenozide
What is tebufenozide?
Tebufenozide, the chemical name is 1-(1,1-dimethylethyl)-1-(4-ethylbenzoyl)-3,5-dimethylbenzoylhydrazide, Cas 112410-23- 8 is an ecdysone-type insecticide, and is known as the three epoch-making insecticide varieties together with Fipronil and Bromchlor.
Pesticide Tebufenozide is a new non-steroidal insect growth regulator and the latest researched insect hormone insecticide.
Tebufenozide Properties
The insecticide tebufenozide is a white solid, m.p.191°C, vapor pressure 3.0×10-6Pa (25°C), relative density 1.03 (20°C), partition coefficient Chemicalbook 4.25, solubility in water at 25°C is 1mg/L , Slightly soluble in organic solvents, stable at 94°C for 7 days, stable at 25°C and pH 7 in aqueous solution under light.
Tebufenozide physical and chemical properties
The insecticide tebufenozide is a white powder. Melting point 191°C; solubility in water (20°C), little solubility in other solvents, stable for 7 days at 94°C, stable under light at 25°C, PH=7 aqueous solution. The vapor pressure is 3×10-8mmHg (25°C). KOWlogP=4.25 (PH=7). Tebufenozide is an ecdysone insecticide, which can cause pests to molt and die by interfering with the normal development of insects. It has low toxicity and the acute oral LD50 of rats is greater than 5000mg/kg. It is safe and harmless to humans, mammals, fish and earthworms , very safe to the environment, is an ideal and safe insecticide in comprehensive control. Its pure product is white solid.
Features of tebufenozide
The insecticide tebufenozide has the same insecticidal characteristics and main uses as hydrazine, but its activity is higher than that of hydrazine. The insecticidal mechanism is to promote the molting of Lepidoptera larvae. When the larvae eat the medicine, they will produce a molting reaction when they should not be molting, and start molting. The inability to molt completely results in dehydration, starvation and death of the larvae. It is effective for both young and old larvae. When the larvae feed on the leaves of the crops sprayed with the pesticide, they stop eating in about 6-8 hours, no longer harm the crops, and begin to die after 3-4 days. Products include 20%, 24% suspending agent and so on.
Features of tebufenozide
The insecticide tebufenozide has broad-spectrum, high-efficiency, low toxicity and other characteristics, and has stimulating activity on insect ecdysone receptors. The mechanism of action is that larvae (especially Lepidopteran larvae) molt when they should not molt after feeding. Due to incomplete molting, the larvae are dehydrated and starved to death. At the same time, they can control the basic functions of insects during reproduction, and have a strong chemical sterilization effect.
The insecticide tebufenozide is a new non-steroidal insect growth regulator and the latest researched insect hormone insecticide. Tebufenozide has high insecticidal activity and strong selectivity. It is effective against all Lepidoptera larvae, and has special effects on resistant pests such as cotton bollworm, cabbage caterpillar, diamondback moth, and beet armyworm. Safer for non-target organisms. Tebufenozide is non-irritating to eyes and skin, has no teratogenic, carcinogenic, and mutagenic effects on higher animals, and is very safe to mammals, birds, and natural enemies.
1. It is a new type of non-steroidal insect growth regulator and a newly developed insect hormone insecticide. It has an agonizing effect on the pest molting hormone receptor, can accelerate the abnormal molting of the pest, and inhibit feeding, causing the pest to suffer from physiological disorders and starvation to death.
2. It is mainly effective through stomach poisoning, but also has certain contact and strong ovicidal activity.
3. After the pests feed, they can interfere with and destroy the original hormone balance in the insects, and cause food refusal. Generally, after 5 hours of feeding, the pests stop harming, and the molt reaction occurs in 1-2 days, and incomplete molts and food refusal occur in 2-3 days. , the whole body loses water, and eventually dies, reaching the peak of dead insects in about 3 days.
4. It has a good ability to kill eggs, and the pests will form chemical sterilization after eating, so the effective period is longer, generally about 15-30 days.
5. It is highly safe, has no phytotoxic reaction, and can cause chemical sterilization of some lepidopteran pests after use. At the same time, there will be a second dead insect period after 10 days, and it has no toxic side effects on bees and predatory mites, so it is highly Safety.
Uses of tebufenozide
The insecticide tebufenozide is mainly used to control citrus, cotton, ornamental crops, potatoes, soybeans, tobacco, fruit trees and vegetables Aphididae, Leafhoppers, Lepidoptera, Liriomyza, Tetranychidae, Thysanoptera , root wart nematodes, Lepidoptera larvae such as pear borer, grape tortrix, beet armyworm and other pests. This product is mainly used for a duration of 2 to 3 weeks. It has special effects on Lepidoptera pests. High efficiency, the dosage per mu is 0.7~6g (active substance). For fruit trees, vegetables, berries, nuts, rice, forest protection.
The insecticide tebufenozide is a novel accelerator for insect desquamation, which has special effects on Lepidoptera insects and larvae, and has certain effects on selective Diptera and Daphnia insects. It can be used for vegetables (cabbage, melon, nightshade, etc.), apples, corn, rice, cotton, grapes, kiwi, sorghum, soybeans, sugar beets, tea, walnuts, flowers and other crops.
The insecticide tebufenozide is a safe and ideal agent. The best time to apply the pesticide is the egg incubation period, and 10-100g of active ingredients/hm2 can effectively control pear borer, grape tortler, beet armyworm, etc., and the persistence period can reach 14-20d. The purpose is a high-efficiency, low-toxic insect growth regulator insecticide. It is mainly used to control cabbage and beet armyworm, etc.
The insecticide tebufenozide has gastric toxicity and is an insect molting accelerator, which can induce Lepidoptera larvae to produce molting reactions in advance before entering the molting stage. Stop feeding within 6-8 hours after spraying, dehydrate within 2-3 days, starve and die.
Toxicity of tebufenozide
Acute oral LD50 in rats and mice>5000mg/kg; acute percutaneous LD50 in rats>5000mg/kg; eye irritation, skin irritation: very little; mutagenicity: negative; environmental toxicity: 8-day daily food intake of wild ducks LC50>5000mg /kg, rainbow trout 96 hours LC50: 5.7mg/L, Daphnia 48 hours EC503.8mg/L, honeybees 96 hours exposure to LD50>234μg/monkey, no effect on the growth of young bees; beneficial arthropods: in laboratory conditions Next, tests on carnivorous ladybugs, carnivorous mites and some carnivorous wasps and spiders etc. were negative
How to use tebufenozide
①To control pests such as jujube, apple, pear, peach and other fruit tree leaf rollers, borers, various gnats, various caterpillars, leaf miners, and inchworms, spray with 20% suspending agent 1000-2000 times liquid.
②To control the resistant pests of vegetables, cotton, tobacco, grain and other crops, cotton bollworm, diamondback moth, cabbage caterpillar, beet armyworm and other Lepidoptera pests, spray with 20% suspending agent 1000-2500 times liquid.
Tebufenozide usage technology
1. To control forest pine caterpillars, spray with 24% suspending agent 2000-400 times liquid.
2. To control the beet armyworm of cabbage, during the hatching period, use 67-100 grams of 20% suspending agent per mu, and spray 30-40 kg of water.
3. To control jujube, apple, pear, peach and other fruit tree leaf rollers, borer moths, various gnats, various caterpillars, leaf miners, inchworms and other pests, spray with 20% suspending agent 1000-2000 times liquid.
4. To control the resistant pests of vegetables, cotton, tobacco, grain and other crops, cotton bollworm, diamondback moth, cabbage caterpillar, beet armyworm and other Lepidoptera pests, spray with 20% suspending agent 1000-2500 times liquid.
The effect of the drug on eggs is poor, and the effect of spraying on the early stage of larvae is good. Tebufenozide is toxic to fish and aquatic vertebrates, and highly toxic to silkworms. Do not pollute water sources when using it; it is strictly forbidden to use it in silkworm breeding areas.
What pests can Tebufenozide control?
The insecticide tebufenozide is mainly used to control citrus, cotton, ornamental crops, potatoes, soybeans, tobacco, fruit trees and vegetables Aphididae, Leafhoppers, Lepidoptera, Liriomyza, Tetranychidae, Thysanoptera , root wart nematodes, Lepidoptera larvae such as pear borer, grape tortrix, beet armyworm and other pests. This product is mainly used for a duration of 2 to 3 weeks.
Effective against Lepidoptera pests. High efficiency, the dosage per mu is 0.7~6g (active substance). For fruit trees, vegetables, berries, nuts, rice, forest protection.
Tebufenozide production method
Preparation method one
2,2,2-Trichloro-(4-ethylphenyl)ethanone is prepared by Fourier reaction of ethylbenzene and trichloroacetyl chloride. Add 21.2g (0.2mol) of ethylbenzene, 80mL of carbon disulfide and 37.5g of anhydrous aluminum trichloride to the reaction flask, add 40g (0.22mol) of trichloroacetyl chloride dropwise in an ice-salt bath, and finish the dropwise addition within 2 hours. Stirring was continued for 6 h, and the reaction solution was poured into a mixture of 234 mL hydrochloric acid and 486 mL ice water, and the layers were separated. The aqueous layer was extracted with 100 mL of carbon disulfide, the carbon disulfide layers were combined, and the carbon disulfide solvent was removed under reduced pressure to obtain 30.6 g of a brown oil, which was purified by column chromatography to obtain a light yellow viscous liquid. Preparation of N-(4-ethylbenzoyl)-N-tert-butylhydrazine 2.37g of tert-butyl hydrochloride was dissolved in 2mL of water, and 7.5mL of dichloromethane and 1.5g of sodium hydroxide were added. Under nitrogen protection, 5 g of 2,2,2-trichloro-(4-ethylphenyl)ethanone was added dropwise at room temperature, and the addition was completed within 15 minutes. After continuing to react at room temperature for 6 h, stop feeding nitrogen, add 0.3 g of 50% sodium hydroxide, and stir overnight. The next day, the mixture was separated, washed with water, and dissolved to obtain 3.56 g of a light yellow solid, which was recrystallized from n-hexane-ethyl acetate to obtain white needle-like crystals. Synthesis of tebufenozide Dissolve 2.2g of N-(4-ethylbenzoyl)-N'-tert-butylhydrazine in 30mL of toluene and keep the temperature at 5-10°C. Add 1.7g of 3,5-dimethylbenzoyl chloride dissolved in 5mL of toluene and 0.8g of 50% sodium hydroxide solution dropwise within 30min. Then warmed up to room temperature and stirred for 3h. Add 10 mL of n-hexane to dilute, filter and wash with water to obtain 3 g of white solid. After recrystallization from ether-methanol, tebufenozide was obtained in the form of white needles.
Preparation method 2 Synthesize tebufenozide starting from p-ethylbenzoic acid.
Preparation methods Trioxadiazole ring-opening synthesis tebufenozide.
Preparation method 4 Synthesize tebufenozide by protecting the amino group.
Precautions for tebufenozide
1. When opening the package, you should wear gloves, masks, and protective clothing. Please open the product as shown by the arrow; do not discard the used package casually, it should be recycled and stored, and destroyed.
2. Wear protective clothing and gloves when processing this product to avoid inhaling the powder. Eating and drinking are not allowed in the processing workshop. Wash your hands and face in time after processing.
3. In case of fire, use a fire extinguisher to extinguish the fire; if it is spilled, it should be cleaned up immediately, and the garbage should be collected and destroyed uniformly.
4. Avoid polluting water sources.
5. This product can be used up to 3 times per crop, and the safe interval is 21 days.
6. This product cannot be mixed with alkaline substances.
7. This product is poisonous to bees, fish and other aquatic organisms and silkworms. During the application period, the influence on the surrounding bee colonies should be avoided, and it is forbidden to use near the silkworm rooms and mulberry gardens during the flowering period of flowering plants. Apply pesticides away from aquaculture areas, and it is forbidden to wash pesticide application equipment in rivers and other waters.
8. The residual liquid cannot be spilled casually, and the unused remaining agent should be sealed and stored in a safe place.
9. Wear protective equipment, gloves and a mask when applying the medicine, avoid splashing the medicine liquid on the eyes and skin, avoid inhalation through the mouth and nose, and wash your hands and face with soap after applying the medicine.
10. It is recommended to rotate with other insecticides with different mechanisms of action.
11. It is forbidden to raise fish or shrimps and crabs in paddy fields, and the field water after spraying must not be directly discharged into the water body.
12. Trichogramma and other natural enemies are prohibited in the flying area.
13. The used containers should be disposed of properly and should not be discarded at will.
14. It is recommended to use it 4 times a year, with a safety interval of 14 days. It is toxic to fish and aquatic vertebrates, and highly toxic to silkworms. Do not spray directly on the water surface. Waste liquid should not pollute water sources. It is forbidden to use this drug in silkworm and mulberry garden areas.
15. Store in a dry, cool, well-ventilated place, away from food and feed, and out of reach of children.
16. The effect of the drug on eggs is poor, and the effect of spraying on the early stage of larvae is good.
Comparison of indoxacarb, chlorfenapyr, lufenuron, and tebufenozide
Mechanism comparison and analysis of four types of insecticides
Chlorfenapyr: Stomach toxicity and contact killing effect, strong permeability on plant leaves, certain systemic effect, no ovicidal function;
Indoxacarb: Stomach toxicity and contact action, no systemic action, no ovicidal function;
Tebufenozide: Stomach toxicity and limited contact action, no osmosis and phloem systemic activity, high ovicidal activity;
Lufenuron: Stomach toxicity and contact action, no systemic action, strong ovum killing.
These four types of compounds are mainly gastric poisoning. If they are applied with penetrants/extenders (mostly silicone-based), the insecticidal effect will be greatly improved.
Comparative analysis of insecticidal spectrum of four kinds of insecticides
Chryprofen: It has good control effect on borers, piercing and chewing mouthparts and chewing pests, as well as some mites, especially against diamondback moth, beet armyworm, litura, leaf roller, pod borer, thistle Horses, some red spiders, etc. have excellent killing effect;
Indoxacarb: mainly used to control Lepidopteran pests such as beet armyworm, diamondback moth, corn borer, Spodoptera litura, cotton bollworm, tobacco budworm, leaf roller moth, and two-spotted armyworm;
Tebufenozide: It is mainly effective against most Lepidoptera pests, and has special effects on cotton bollworm, cabbage caterpillar, diamondback moth, beet armyworm, etc.;
Lufenuron: It is mainly used to control pests such as leaf roller, diamondback moth, cabbage caterpillar, beet armyworm, spodoptera litura, whitefly, thrips, rust tick and other pests, and has outstanding control effect on rice leaf roller.
Insecticidal broad-spectrum: Chlorfenapyr > Lufenuron > Indoxacarb > Tefenozide
Comparison and analysis of four types of insecticides in killing speed
Chlorfenapyr: 1 hour after normal spraying, the activity of the pests began to weaken, the color of the insects changed, the activities gradually stopped, and behavioral characteristics such as coma and paralysis appeared, which eventually led to death, and reached the peak of dead insects within 24 hours;
Indoxacarb: After spraying, the insects will stop feeding within 4 hours, the insects will be paralyzed and comatose, and their mobility will be significantly reduced (usually nymphs will fall from the crops), and generally die within 1 to 3 days after spraying;
Tebufenozide: After the pesticide is fed by the pest, it can interfere and destroy the original hormone balance in the insect body, and cause food refusal. Generally, the pest stops harming after 5 hours of feeding, and the peeling reaction occurs in 12 days, and it leads to incompleteness in 2 to 3 days. Peeling, refusal to eat, dehydration of the whole body, and eventually death, reaching the peak of dead insects in about 3 days;
Lufenuron: The nerves of the pests are paralyzed within 2 hours after they come into contact with the pesticide and eat the leaves with the pesticide, and gradually stop feeding, and reach the peak of dead insects in 3 to 5 days.
The rate of death: chlorfenapyr > indoxacarb > tefenozide > lufenuron.
Comparison and Analysis of Four Types of Insecticides' Persistence Period
Chlorfenapyr: does not kill eggs, has outstanding control effect on older insects, and the duration of effect is about 7 to 10 days;
Indoxacarb: does not kill eggs, but kills lepidopteran pests regardless of size, and the duration of effect is about 12 to 15 days;
Tebufenozide: good egg killing ability, chemical sterilization will be formed after the pests feed on it, and the duration of effect is long, about 15-30 days;
Lufenuron: It has a strong ovicidal effect, and the insect control time is relatively long, up to 25 days.
Persistence period: lufenuron > tebufenozide > indoxacarb > chlorfenapyr
Safety comparison and analysis of four types of pesticides
Lufenuron: Market feedback shows no harm;
Chlorfenapyr: According to current market feedback, it is only relatively sensitive to cruciferous vegetables and melon crops, and there will be certain safety risks when used at high temperatures or high doses;
Indoxacarb: Highly safe, no harmful reactions;
Tebufenozide: High safety factor, no phytotoxicity reaction, and can cause chemical sterilization of some lepidopteran pests after use, and there will be a second dead insect period after 10 days.
Safety: tebufenozide>indoxacarb>lufenuron>chlorfenapyr
However, chlorfenapyr is very safe for crops (soybean, corn, peanut) in the current northern summer crop area.
Of course, the combination of different schemes is to achieve different purposes. In my opinion, the scheme that can achieve the perfect combination of quick-acting effect (acting after 1 hour) + long-lasting effect (strong egg killing) should be chlorfenapyr + lice Fenuron can truly achieve the ultimate goal of saving labor, time and money for farmers.
Since most insecticides are frequently used or used in high doses, resistance will quickly develop. When we use medicines, we must still abide by the principle of "prevention first, comprehensive prevention and control", not only do a good job of chemical rotation, but also delay the emergence of resistance , it is even more important to choose medication when the age of the insects is relatively small, which can make the killing effect more prominent.
The price of the insecticide tebufenozide
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