Microbial Fungicides Difenoconazole
What is Difenoconazole?Difenoconazole is a highly effective and broad-spectrum triazole systemic fungicide that is primarily used to control grey rot, downy mildew and powdery mildew on fruits, vegetables and other agricultural crops.Cas 119446-68-3 Difenoconazole is a member of the class of dioxolanes that is 1,3-dioxolane substituted at position 2 by 2-chloro-4-(4-chlorophenoxy)phenyl and 1,2,4-triazol-1-ylmethyl groups. A broad spectrum fungicide with novel broad-range activity used as a spray or seed treatment. It is moderately toxic to humans, mammals, birds and most aquatic organisms.
It has a role as an environmental contaminant, a xenobiotic, an EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor and an antifungal agrochemical. It is an aromatic ether, a dioxolane, a member of triazoles, a cyclic ketal, a conazole fungicide and a triazole fungicide.
Difenoconazole is a fungicide used for disease control in many fruits, vegetables, cereals and other field crops. Although potentially a mobile molecule it is unlikely to leach due to its low aqueous solubility. It does however have potential for particle bound transport.
It is slightly volatile, persistent in soil and in the aquatic environment. There are some concerns regarding its potential for bioaccumulation. Moderately toxic to humans, mammals, birds and most aquatic organisms.
Difenoconazole Mode of Action
Difenoconazole is a DMI Triazole systemic fungicide.
It Provides prevention and cure. It is absorbed by the leaves with acropetally and shows strong translaminar translocation.
It stops the development of fungi by interfering with the biosynthesis of sterols in cell membranes. Long-lasting preventive activity combined with curative and eradicant properties; fast uptake and high translaminar movement.
Difenoconazole Key Properties
A systemic fungicide with a novel broad-range activity protecting the yield and crop quality.
Provides preventive and curative activity against Ascomycetes (e.g. powdery mildew), Basidomycetes (e.g. rusts & smuts) and Deuteromycetes (e.g. blights & downy mildew).
Shows excellent crop compatibility.
Can mixed with other fungicides & insecticides.
Features of Difenoconazole
Systemic conduction, wide bactericidal spectrum
Within 2 hours after spraying, it will be absorbed by the crops and has the characteristics of upward conduction, which can protect the new young leaves, flowers and fruits from the harm of pathogens. It can cure multiple diseases with one medicine, and has a good control effect on various fungal diseases. It can effectively control vegetable scab, leaf spot, powdery mildew and rust, and has both preventive and therapeutic effects.
Resistant to rain erosion, long-lasting effect
The pesticide adhered to the leaf surface is resistant to rainwater erosion, and has little volatilization from the leaves. Even under high temperature conditions, it has a long-lasting bactericidal activity, which is 3-4 days longer than ordinary fungicides.
Advanced dosage form, crop safety
Water-dispersible granules are composed of active ingredients, dispersants, wetting agents, disintegrants, defoamers, binders, anti-caking agents and other additives, and are granulated through micronization, spray drying and other processes. It can be quickly disintegrated and dispersed when put into water, forming a high-suspension dispersion system without dust influence, which is safe for users and the environment. Free of organic solvents, safe for recommended crops.
Wide range of mixing
Difenoconazole can be mixed with fungicide ingredients such as propiconazole and azoxystrobin to produce compound fungicides.
Microbial Fungicides Difenoconazole price
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What is the use of difenoconazole fungicide?
Difenoconazole is a broad spectrum fungicide that controls a wide variety of fungi – including members of the Aschomycetes, Basidomycetes and Deuteromycetes families. It acts as a seed treatment, foliar spray and systemic fungicide. It is taken up through the surface of the infected plant and is translocated to all parts of the plant. It has a curative effect and a preventative effect. Difenoconazole can be applied to winter wheat, oilseed rape, Brussels sprouts, cabbage, broccoli/calabrese and cauliflower. It controls various fungi including Septoria tritici, Brown Rust, Light Leaf Spot, Leaf Spot, Pod Spot, Ring Spot and Stem canker. It also prevents Ear Discolouration in winter wheat. The mode of action of difenoconazole is that it is a sterol demethylation inhibitor which prevents the development of the fungus by inhibiting cell membrane ergosterol biosynthesis.
It's a dual systemic broad-spectrum fungicide with protective and curative action. It offers not only disease control but also improves crop health, quality and yield of a crop. Used for control of a wide variety of fungal diseases in various crops.
Difenoconazole can be applied to winter wheat, oilseed rape, Brussels sprouts, cabbage, broccoli/calabrese and cauliflower. It controls various fungi including Septoria tritici, Brown Rust, Light Leaf Spot, Leaf Spot, Pod Spot, Ring Spot and Stem canker. It also prevents Ear Discolouration in winter wheat.
Effective Use of Difenoconazole
Sensitive varieties. On non-vinifera grapes, especially V. labrusca and V. labrusca hybrids, difenoconazole may cause leaf burning or other injury. Adding difenoconazole to tank mixtures with materials that increase uptake (adjuvants, foliar fertilizers) may increase the risk of injury.
Use an effective rate. Inspire Super at the high rate (20 oz/ac) and Revus Top at the supplemental label rate (7 oz/ac) provide equivalent amounts of difenoconazole per acre, about 1/4 of the seasonal limit.
Adjust your spray program for the premix. When applying Revus Top, omit other DM materials such as mancozeb and captan from those sprays. For Inspire Super, omit any other botryticide from those sprays.
Resistance management. Limit applications of any SI, including difenoconazole, to two per year, if possible. Rotate to another class of fungicide after each SI application.
Applications of Difenoconazole
Difefeconazole is a triazole fungicide with systemic properties and is a sterol demethylation inhibitor with a broad bactericidal spectrum. It is a triazole fungicide with systemic property and wide bactericidal spectrum. It is a sterol demethylation inhibitor. Broad bactericidal spectrum, used for foliar treatment or seed treatment.
It is used to prevent sheath blight, rust, early blight, leaf spot, scab and powdery mildew on grapes, peanuts, pome fruits, potatoes, wheat and vegetables and other crops.
Difenoconazole is mainly used for prevention and supplemented by treatment. When preventing and curing diseases, it must be used before or at the beginning of the disease. The control effect on diseases is better, and it can also stimulate crop growth.
Difenoconazole has good compatibility and significant synergistic effect. When using it, it should be mixed with other fungicides and insecticides as much as possible. This not only expands the scope of control, improves the efficacy, but also delays drug resistance.
Difenoconazole Recommendations
Start spraying at the appearance of 1st disease symptom OR when the environmental conditions are favorable for disease appearance, start spraying as preventive.
Repeat the application at 10-14 days interval.
Interval of sprays can be changed according to the intensity of disease.
Use hollow cone nozzles for spray and ensure the thorough coverage of crop.
Crops Pests Dose
Potato Early & Late Blight 120 ml / acre
Tomato Early & Late Blight 50 ml / 100 Lit of water
Cucurbits Powdery Mildew, Downy Mildew 120 ml / acre
Apple Powdery Mildew 30 ml / 100 Lit of Water
Mango Powdery Mildew, Anthracnose 50 ml / 100 Lit of Water
Grams Gram Blight 120 ml / acre
Is difenoconazole a fungicide?
Difenoconazole is one of the most commonly used fungicides to prevent and treat plant diseases caused by certain fungi. Due to increasing usage, more difenoconazole has been released into the environment and caused environment pollution. However, the potential impact of difenoconazole on plant growth and development and its involved mechanism are unclear.we discovered that difenoconazole exposure significantly inhibited plant growth, evidenced by the decrease in root dry weight, total root length, and surface area by 20–70%, 43–73%, and 26–66%, respectively, under different regimes of treatment concentrations and periods. Difenoconazole exposure also significantly inhibited shoot growth and development by decreasing 33–61% of the shoot dry weight and 50–65% of the leaf area. Difenoconazole exposure induced plant leaf cells to generate more ROS (O2•− and H2O2) and MDA, which resulted in a decreased chlorophyll content and then inhibited leaf photosynthesis. Difenoconazole exposure also induced the activities of superoxide dismutase (SOD), catalase (CAT), guaiacol peroxidase (G-POD), and ascorbate peroxidase (APX) in the roots and leaves of the wheat seedlings. SOD and APX activities were higher and more stable in the roots than those in the leaves.plant roots exhibited a more pronounced superoxide radical scavenging ability than plant leaves. In summary, difenoconazole exposure caused oxidative stress, reduced chlorophyll biosynthesis and functions, and then inhibited wheat plant growth and development.
Is difenoconazole a triazole fungicide?
It belongs to the group of triazole fungicides, metabolized to free triazole compounds 1,2,4-triazole, triazole alanine, and triazole acetic acid.DFC was firstly described in 1988 as a novel demethylation inhibitor and it became widespread for its excellent fast-acting and prominent systemic activity.
Is difenoconazole systemic?
Crops and Pest Groups: Difenoconazole is a systemic fungicide which is used for the control of scab of Apple, leaf spot and rust of Groundnut, blight & powdery mildew in Cumin, purple blotch in Onion, fruit rot in Pomegranate and anthracnose and powdery mildew in Grapes.
Is azoxystrobin fungicide safe?
Azoxystrobin is of low toxicity and consequently low risk to birds, mammals, bees and other non-target terrestrial organisms. Although highly toxic to aquatic organisms, actual field use of azoxystrobin results in a low risk of effects due to azoxystrobin's low application rates and dissipation rate in the environment.
What is the difference between propiconazole and difenoconazole?
Propiconazole Stops the development of fungi by interfering with the biosynthesis of sterols in cell membranes. Difenoconazole is a sterol demethylation inhibitor that prevents the development of the fungus by inhibiting cell membrane ergosterol biosynthesis.
Difenoconazole precautions
It is particularly effective against newly infested germs. Therefore, spraying difenoconazole in time after the rainfall can eradicate the source of the initial fungus, and will play a good role in controlling the development of the disease in the later stage of growth.
It should not be mixed with copper-containing agents. It can be mixed with most insecticides and fungicides, but a mixing test must be done before application.
In order to prevent pathogens from developing resistance to difenoconazole, it is recommended that the number of spraying of difenoconazole should not exceed 4 times in each growing season. It should be used alternately with other pesticides.
In the early stage of the disease, use low doses with long intervals; when the disease is severe, use high doses with short intervals; during the epidemic period with lush plant growth, suitable temperature, high humidity, and heavy rain, use high doses with short intervals and increase the number of medications , to ensure the effect of disease prevention and production increase. No growth inhibitory effect on vegetables.
Poisonous to fish, do not pollute water sources. Avoid storage below 10°C and above 30°C.
Pay attention to safety protection when using the medicine. If the medicine splashes into the eyes, immediately rinse the eyes with water for at least 10 minutes; if swallowed by mistake, immediately send to the hospital for symptomatic treatment. There is no special antidote for this medicine. The remaining liquid medicine and washing wastewater cannot pollute fish ponds, pools and water sources.