Nitenpyram insecticide uses in agriculture
What is insecticide nitenpyram?Nitenpyram is an insecticide used in agriculture and veterinary medicine to kill external parasites of pets. It is a neonicotinoid, a neurotoxin that blocks neural messages and binds particularly tightly in the central nervous system of insects, causing rapid death.Nitenpyram is an antiparasitic drug used for treatment of fleas.Cas150824-47-8 It rapidly kills adult fleas. It is from the class of synthetic insecticides known as the neonicotinoids. It is related to imidacloprid and has the same mechanism of action, which is to inhibit postsynaptic nicotinic acetylcholine receptors, which produces influx of sodium ions.
Nitenpyram is a chemical frequently used as an insecticide in agriculture and veterinary medicine. The compound is an insect neurotoxin belonging to the class of neonicotinoids which works by blocking neural signaling of the central nervous system. It does so by binding irreversibly to the nicotinic acetylcholine receptor (nACHr) causing a stop of the flow of ions in the postsynaptic membrane of neurons leading to paralysis and death. Nitenpyram is highly selective towards the variation of the nACHr which insects possess, and has seen extensive use in targeted, insecticide applications.
Mechanism of action insecticide nitenpyram
Neonicotinoids are the largest group of insecticides used in today's agricultural world and prevalent in veterinary treatments, toxicity in general, e.g., genotoxicity and biotransformation, remains among the most controversial matters on the topic of neonicotinoids.This is primarily due to the lack of concrete systematic work.studies have been done on binding phenomena between neonicotinoids and proteins, serving as an indicator to its likely behavior in human physiological conditions.
Nitenpyram a synthetic, nicotine-related chemical (neonicotinoid), has an effect on the nicotinic acetylcholine receptors and, for this reason, is considered similar to nicotine (agonists). Nicotinic acetylcholine receptors are involved in the sympathetic and parasympathetic nervous systems, present on the muscle cells where the cells from the nervous systems and the muscle cells form synapses. Variations in nicotinic-acetylcholine-receptor-binding affinity persists between species.
Nitenpyram is an agonist of nicotine for the nicotinic acetylcholine receptor, it has a much lower affinity for the nicotine acetylcholine receptor in mammals. For most insects nitenpyram is a very lethal compound. Nitenpyram will bind irreversibly to the nicotinic acetylcholine receptors, paralysing those exposed to the compound. Despite lower affinity levels, mammals can still get a nicotine poisoning response from too much neonicotinoids, hence it is of importance to provide the appropriate dose for a flea-infested pet and it's always best to consult a vet.
How does it work Agricultural applications insecticide nitenpyram?
Being one of the first generation neonicotinoids, nitenpyram has seen extensible commercial use since its introduction, including pest control in agriculture. While the development of newer generation nicotinoids has caused a decrease in its use, a Worldwide Integrated Assessment (WIA) report still judged it as an ecologically viable treatment in pest control projects such as Integrated Pest management (IPM). This is due to its lower toxicity and high uptake in plants in relation to soil as opposed to other commercially used neonicotinoids.
Nitenpyram has been used on many commercial crops, such as cotton and corn,and can be applicated in various ways.Commonly used techniques are dusting and seed treatment. Seed treatment allows for a long lasting immunity to insects damaging the crops. The use of nitenpyram has been shown to be highly effective in protecting crops, as it is generally less toxic for non-target organisms, while killing off crop-destroying insects.The reason for this is not yet fully understood, as other first generation neonicotinoids do not seem to follow the same trend, and nitenpyram is known to be less toxic to non-target organisms as compared to the compounds of the same generation.
Side effects
Due to its use on pollen carrying plants, nitenpyram has been linked to a decrease in population of pollinators such as honey bees, wild bees and butterflies.such as earthworms, are also reported to be negatively affected by nitenpyram. Plants themselves do not seem to have a negative response, as they do not possess nicotine nACh receptors.
What is the use of nitenpyram insecticide?
Nitenpyram tablets are used to treat flea infestations in cats and dogs.After oral administration of the tablet the drug is readily and quickly absorbed into the blood. If a flea bites the animal it will ingest with the blood the nitenpyram. The effect of nitenpyram can be observed half an hour after the administration. At this time a high concentration in the plasma can be detected and the first fleas dislodge from the pet host. A study showed that six hours after application the infestation of fleas on decreased by 96.7% for dogs and 95.2% for cats.The adult fleas present on the hosts are severely interrupted, hence, egg production is reduced. Eggs are not directly affected by nitenpyram, only after they come out. Administering nitenpyram might have to be repeated or continued until the pest infestation has subsided. The half life of nitenpyram is around eight hours. Thus, 24 hours after treatment roughly 100% of the adult fleas were killed.
Insecticide nitenpyram price
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Insecticide nitenpyram supplier
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Advantage insecticide nitenpyram
Nitenpyram it has strong systemic effects and can kill insects by contact and cause gastric toxicity. After application, the drug can be quickly absorbed by the roots and leaves of crops and transported to various parts of the plant. It has good effects in controlling piercing-sucking pests such as whiteflies and scale insects.
Nitenpyram it has a unique insecticidal mode of action that can destroy the nervous system of insects and knock them down quickly. The mouth parts of piercing-sucking pests would be paralyzed and permanently blocked, and then they immediately stop damaging the crop due to inability to feed normally and starve to death.
Resistant to rain wash, good enduring effects in controlling rice planthoppers.It has high efficiency and low toxicity and is safe to crops. The Water Dispersible Granule formulation is advanced and environmentally friendly.
physical properties insecticide nitenpyram
Nitenpyram ( (E)-N-(6-Chloro-3-pyridylmethyl)- N-ethyl-N'-methyl-2-nitrovinylidenediamine) is an open-chain chloropyridyl neonicotinoid. Nitenpyram consists of a chloronicotinyl heterocyclic group common to all first generation neonicotinoids and a pharmacophore, the reactive group of the molecule. Nitenpyram possesses a nitroamine pharmacophore which is known to be the main reaction site in the binding of the compound to the nACh receptor, though the specificity of the reaction is not yet fully understood for neonicotinoids in general.Due to its polar groups, nitenpyram is quite hydrophilic, with an extremely high water solubility.
How quickly does it kill fleas insecticide nitenpyram?
nitenpyram is fleas begin to die approximately 30 minutes after dosing, and the effects will last up to 24-48 hours.
How is insecticide nitenpyram given?
Nitenpyram is given by mouth in the form of a tablet. It should be given with a meal.
This medication will take effect quickly, in about 1 to 2 hours, and improvement in clinical signs should follow.
Are there any potential side effects insecticide nitenpyram?
nitenpyram side effects are uncommon. Rarely reported side effects include increased or decreased energy, itching, vomiting, diarrhea, or lack of appetite. Serious side effects include trouble breathing, drooling, stumbling, weakness, seizures, hives, excessive panting, and big pupils.
This short-acting medication should stop working within 24 hours, although effects can be longer in pets with liver or kidney disease.
Are there any drug interactions I should be aware of insecticide nitenpyram?
There are no specific drug interactions with nitenpyram. Be sure to tell your veterinarian about any medications (including vitamins, supplements, or herbal therapies) that your pet is taking.
Cautions insecticide nitenpyram
Note that this product has poor effects in controlling rice brown planthoppers.
Do not use it in shrimp, crab and rice intercropping fields. After application, the water in the field should not be discharged directly into other waters.
Do not get into where the drug is applied within 12 hours after the application.
This product is highly toxic to silkworms and bees. It is forbidden to use it in bee-keeping regions and in the flowering period of flowering plants, and it should not be used directly in mulberry orchards. Apply this agent far from water bodies such as aquaculture areas, rivers and ponds, and do not wash drug application implements in water bodies such as rivers and ponds.