Non fumigable organophosphate nematicidal insecticide fosthiazate
What is fosthiazate (98886-44-3)?
The insecticide fosthiazate is an organic compound with the chemical formula C9H18NO3PS2. Cas 98886-44-3 is a light yellow liquid with a vapor pressure of 5.6×10-4 Pa (25℃). The acute oral LD50 of toxicity in rats is 57~73 mg/kg. It is an organophosphorus nematicide. Its main mode of action is to inhibit the synthesis of acetylcholinesterase in root-knot nematodes. It can be used to control various types of root-knot nematodes, aphids, etc. In China, it has been registered on cucumbers, tomatoes, and watermelons, and can be widely used in vegetables, bananas, fruit trees, medicinal materials and other crops.
The insecticide fosthiazate is mainly used to control nematodes, aphids, etc. It is one of the few nematode-killing products and is suitable for the production of pollution-free vegetables. It has a very good control effect on various nematodes such as root-knot nematodes, root rot nematodes, stem nematodes, and cyst nematodes. It has good plant body conduction as a chemical book. It can prevent invasion and kill nematodes that have already invaded. Effect. The lasting period of annual crops is 2 to 3 months, and the lasting period of perennial crops is 4 to 6 months. The dosage is 1.5 to 2 kg/mu. In Shandong vegetable areas, it is generally used twice a season, with 4 to 6 kg each time.
Mechanism of action of fosthiazate (98886-44-3)
The insecticide fosthiazate can effectively prevent root-knot nematodes in various crops. It can quickly penetrate into the root nodules and kill the root-knot nematodes, allowing the crops to re-grow fibrous roots and restore growth.
fosthiazate (98886-44-3) mode of action
The pesticide fosthiazate is an organophosphorus nematicide. Its main mode of action is to inhibit the synthesis of acetylcholinesterase in root-knot nematodes and can be used to control various root-knot nematodes. It has contact and systemic effects. There are two main ways to kill root-knot nematodes: the nematodes contact fosthiazate in the soil and die; fosthiazate is absorbed into the roots of crops and kills root-knot nematodes that have invaded the roots of crops and formed nodules. It is quick-acting. , long-lasting effect, fosthiazate can still reach the lethal concentration of root-knot nematodes in the soil 2 months after its use, and can still reduce nematode activity after 3 months; fosthiazate has upward conduction characteristics, and is conducted from the roots of the crop to the leaves Strong, weak transmission from leaves to flowers, and basically no transmission from flowers to fruits; it can be transmitted to leaves to control sucking mouthpart pests such as aphids; it has low toxicity, low residue, and meets agricultural product export standards.
fosthiazate (98886-44-3) toxicity
Rat acute oral LD5057～73mg/kg, mouse 91～104mg/kg; rat acute dermal LD502396mg/kg (male), 861mg/kg (female); rat acute inhalation LD500.832mg/L (male) , 0.558mg/L (female). Hens were negative for delayed neurotoxicity. It is chemically irritating to rabbit eyes but not irritating to skin. Carp LD50208mg/L (48h), water flea 2.17mg/L.
fosthiazate (98886-44-3) Chemical Properties
The insecticide fosthiazate appears as a light yellow liquid. B.p.198℃/66.66Pa, vapor pressure 5.6×10-4Pa (25℃), solubility in water 9.85g/L (0.87%), distribution coefficient 1.75.
Characteristics of fosthiazate (98886-44-3)
1. The insecticide fosthiazate directly kills root-knot nematodes, with a control effect of more than 90%.
2. The pesticide fosthiazate has a long lasting effect, which can reach 2 to 3 months; it has good properties and the nematodes can be observed under a microscope to be basically dead within 24 hours after use; the color of the crop root nodules can be observed in 4 to 6 days. Changes: fibrous roots will grow longer and longer in 6-8 days, and crop growth will recover significantly in 15 days.
3. The use period of the insecticide fosthiazate is flexible and convenient, and can be used in various growth stages of crops. It prevents nematodes from invading the roots of crops before root-knot nematodes damage. After root-knot nematodes damage, roots can be irrigated to directly kill root-knot nematodes in root nodules.
4. The insecticidefosfosthiazate is safer and does not damage the seedlings or burn the roots.
Applicable crops for the pesticidefosfosthiazate: melons such as luffa, bitter gourd, cucumber, and watermelon; Solanaceae such as peppers, tomatoes, and eggplants; fruit trees such as bananas and citrus; crops such as ginger and potatoes that are seriously affected by root-knot nematodes
fosthiazate (98886-44-3) insecticidal mechanism and scope of action
The insecticide fosthiazate cholinesterase inhibitor causes the neurotransmitter acetylcholine to accumulate, and the choline receptors are repeatedly activated, causing the nematode nerves to become overly excited and die. It has a very good control effect on various nematodes such as root-knot nematodes, root rot nematodes, stem nematodes, and cyst nematodes. It has a good conduction effect in the plant body, can prevent the invasion of nematodes, and can kill nematodes that have already invaded. More importantly, it can also be used to control many pests of the order Thysanoptera, Lepidoptera, Coleoptera, and Diptera on the ground. It is also very effective against underground root pests; it also has good killing activity against many mites.
fosthiazate (98886-44-3) uses
The main mode of action of insecticides and nematicides is to inhibit the acetylcholinesterase of the target pest, affecting the ecology of the second larval stage. It is used to control many pests of the order Thysanoptera, Lepidoptera, Coleoptera, and Diptera on the ground. It is also very effective against underground root pests. It is also effective against many mites. It has good killing activity against various nematodes and is effective against commonly used insecticides. The agent produces antibiotic pests and has good systemic killing activity. Thiazothion is most effective when mixed into the soil immediately after application. It can be applied directly to the soil surface before crop planting, or it can be used when crops are sown. The recommended dosage is 1 to 4kg of active ingredient/hm2.
fosthiazate (98886-44-3) Application
The insecticide fosthiazate is a new type of thiophosphoric acid ester insecticide and nematicide. It has excellent nematicidal activity and significant systemic insecticidal activity. It also has strong killing ability against various pests. In the infiltration treatment of soil, Nematophos also has killing activity against root nodule nematodes in the south. At a dose of 1.6kg (active ingredient)/hm2, Nematophos can well inhibit the generation of root galls. In the soil infiltration treatment, Nematophos has systemic activity against cotton spider mites. Because of its excellent systemic activity, Nematophos can simultaneously remove ground pests and underground nematodes through soil infiltration. . It has excellent killing activity against various nematodes and nematodes. It can be seen from the relatively low logp value. It also has obvious systemic effects on various insects, mites and nematodes. It also has obvious systemic effects on commonly used insecticides. It also has high killing activity against insecticide-resistant pests. Nematophosphorus also has killing activity against house flies.
How to fosthiazate (98886-44-3)
1. Prevention before nematodes invade crops: Use 1 bottle (500ml) of Fuxianbao per mu with water or mix it 2000 times with water to spray and irrigate the transplant nest.
2. Treatment after nematodes invade crops: According to the degree of nematode damage, use 1-2 bottles of Fuxianbao per mu with water or mix it with water 750-1000 times to irrigate the roots.
How to use fosthiazate (98886-44-3)
The pesticide fosthiazate is an organophosphorus nematicide. Its main mode of action is to inhibit the synthesis of acetylcholinesterase in root-knot nematodes. It can be used to control various types of root-knot nematodes, aphids, etc. In China, it has been registered on cucumbers, tomatoes, and watermelons, and can be widely used in vegetables, bananas, fruit trees, medicinal materials and other crops.
The control of root-knot nematodes by the insecticide fosthiazate is mainly reflected in its contact and systemic effects. On the one hand, it can directly kill root-knot nematodes in the soil in contact; on the other hand, it can be absorbed by the plant roots and play a role in destroying nematodes that have formed nodules in the root system.
There are three main ways to use fosthiazate to control root-knot nematodes. The first is to use granules for prevention before planting. Generally, 10%fosthiazatepic granules are selected at 1500-2000g/acre; the second is to use holes. There is a preventive method of application, but it is recommended to use some organic fertilizer or sandy soil and mix it well in advance, which is safer; the third method is to apply with water. After root-knot nematode occurs, according to the degree of occurrence, apply 20% per acre of land. 750-1000ml offosfosthiazate suspension for prevention and control. You can see changes in the roots in 5 to 7 days, and the insect control lasts for about 30 days.
fosthiazate (98886-44-3) production method
Preparation of 2-oxythiazolidine from β-mercaptoethylamine. Dissolve 488mg β-mercaptoethylamine, 3.86g (Ph2PO)2O or [(PhO)2PO]2O and triethylamine in acetonitrile, and pass in CO2 for 1 day. , the reaction temperature is 50~60°C, and 2-oxothiazolidine is obtained. Pass CO (80 mL/min) into a mixed solution of 0.02 mL β-mercaptoethylamine, 0.05 mol triethylamine, 0.05 mol Se and acetonitrile, and react at room temperature to obtain 2-oxothiazolidine, with a yield of 96%. From the methanol solution of 2-oxoxazolidine, the temperature is 70°C, and the resulting mixture is reacted at 90°C for 8 hours to obtain 2-oxothiazolidine, with a yield of 85%. Preparation of S-sec-butyl-O-ethylphosphorothioate chloride, literature reports the preparation example of EtO(PrS)P(O)Cl: react 0.13mol PCl3 with 0.2mol (EtO)3P at 55°C 2h, get a mixture of EtOPCl2 and (EtO)2PCl. Add 35.5% PhMe solution containing 0.325molrPrSCl to the mixture. At this time, the temperature is -20°C, and you can get 72.2% EtO(PrS)P(O)Cl. The mixture is 65g, and the chemical book contains PrSP(O)Cl223.7%, (EtO)2(PrS)PO3.2% and Pr2s20.9%. EtO(PrS)P(O)Cl is further separated. The literature points out that using PCl3 as raw material, S-sec-butyl-O-ethylphosphorothioate chloride can be prepared using a method similar to the above. Synthesis offosfosthiazate by n-butyllithium method: Dissolve 1.5g of 2-oxothiazolidine in 30 mL of tetrahydrofuran, cool, then add n-butyllithium n-hexane solution (1.65mol) dropwise, stir the mixture for 15 minutes, and then add it dropwise A tetrahydrofuran solution containing 10 mL of 5g S-sec-butyl-O-ethylphosphorothioate chloride was added dropwise, and the mixture was stirred for another 30 min, reacted at room temperature for 3 days, poured into water after the reaction, extracted with ethyl acetate, washed with water, dried, and dehydrated. Dissolve 2 to 3 g of the desired product, with a yield of 70% to 90%. Metal sodium method Add toluene and metal sodium into the reactor and raise the temperature to reflux temperature under nitrogen. After the sodium metal is dissolved, stir and disperse, add dropwise the tetraphenyl solution of 2-oxothiazolidine, and continue the reaction for 2 hours after the dropwise addition. Cool to 15°C, add S-sec-butyl-O-ethylphosphorothioate chloride dropwise, and react for another 1 hour. After post-treatment,fosthiazate was obtained with a purity of 96.4% and a yield of 91.2% based on phosphorus oxychloride.
Why is fosthiazate (98886-44-3) not popular?
The insecticide fosfosthiazate has excellent systemic properties. It can not only control nematodes parasitic on the stems and leaves of above-ground plants, but also nematodes parasitic on the roots of underground plants. It can also achieve and bottom-fertilize thiazoids through root application. Amines can have similar effects on above-ground pests during the growing season of plants.
Taking cucumbers as an example, after applying 10% fosthiazate granules, it can not only effectively control root-knot nematodes, but also be effective against aphids, thrips, whiteflies, ladybugs, mites and some lepidopteran pests during the growth period of cucumbers. At the same time, it can also effectively prevent the harm of underground pests such as cutworms, grubs and wireworms. According to feedback from some farmers, the harm of snails and slugs has also been greatly reduced after the application of fosthiazate.
Currently,fosfosthiazate has become the main force in preventing and controlling nematodes. Compared with similar competing products, it is faster-acting than Paecilomyces lilacinus and more thorough in killing insects than abamectin. It has completely replaced traditional highly toxic nematode-killing products, such as Isosophos-methyl, carbofuran, aldicarb, etc. have become the basis for contemporary farmers to prevent and control agricultural nematodes.
First, fosthiazate has a large odor. For production companies, constraints from environmental protection and workers' production environment are the main factors that prevent many companies from large-scale production; for distribution channels, they also have to face strong odors during transportation, warehousing and sales, which makesfosfosthiazate has become one of the least popular pesticides; for end users, odor is also one of the factors affecting market popularity.
Second, the application cost of fosthiazate is relatively high. Taking 10% fosthiazate granules as an example, the market retail price is about 25 yuan/500 grams. Calculated based on the maximum dosage registered by the Ministry of Agriculture of 2,000 grams/mu, the control cost per mu is 100 yuan; the market retail price of 11% avithiazophosphon granules 50 yuan/500 grams, the cost of control per mu is about 200 yuan. However, in practical applications, especially in areas where nematodes are more serious, the actual cost per mu is higher when fosthiazate is used for control.
Compared with the cost of traditional nematode control products such as isosulfan-methyl, carbofuran and aldicarb, the control cost has increased by more than 4 times. Compared with the conventional nematode control product 0.5% abamectin granules, the control cost per mu increased by more than 3 times.
How to use fosthiazate wisely (98886-44-3)
Although the insecticide fosthiazate has not been fully widely used, it can also produce resistance, especially on highly susceptible nematode crops such as vegetables and Chinese medicinal materials with high economic value, and it is necessary to pay attention to the skills and methods of use.
First,fosthiazate is most effective when applied to the soil. It can not only kill nematodes in the soil, but also kill nematodes that enter the internal tissues of the root system through the root tip through root system absorption.
Secondly, fields with more nematodes should be combined with physical control methods such as water irrigation and stuffy sheds.
Again, use it alternately with abamectin. For fields with lighter nematodes, avermectin can be used for prevention and fosthiazate can be used for remediation; for fields with heavier nematodes, fosthiazate can be used for prevention and avermectin can be used for remediation.
Finally, it can be mixed with aminooligosaccharides or gelatin. Both can inhibit the growth of nematodes and release oligosaccharides to promote the death of nematodes. They can also enhance the immunity of crops and improve their ability to resist pests and diseases.
Mixing two pesticides with different insecticidal mechanisms can reduce resistance and reduce the dosage of pesticides.
The application of fosthiazate (98886-44-3) in the control of root-knot nematodes
The pesticide fosthiazate is an organophosphorus pesticide. Its control of root-knot nematodes is mainly reflected in its contact and systemic effects. On the one hand, it can directly kill root-knot nematodes in the soil in contact with it; on the other hand, it can be absorbed by the plant roots and play a role in eliminating nematodes that have formed nodules in the root system!
There are three main ways to use fosthiazate to control root-knot nematodes. The first is to use granules for prevention before planting. Generally, 10%fosthiazatepic granules are selected at 1500-2000g/acre; the second is to use holes. There is a preventive method of application, but it is recommended to use some organic fertilizer or sandy soil and mix it well in advance, which is safer; the third method is to apply with water. After root-knot nematode occurs, according to the degree of occurrence, apply 20% per acre of land. 750-1000ml offosfosthiazate suspension for prevention and control.
Use fosthiazate scientifically to control root-knot nematodes. You can see changes in the roots in 5 to 7 days, and the insect control lasts for about 30 days!
Problems when using fosthiazate (98886-44-3)
The first problem is that excessive use will cause root burning and tree death. Therefore, I would like to remind everyone that you must use it according to the guidance (generally, the dosage of 20% of the mu should not exceed 1.5 kg), and do not blindly increase the dosage of fosthiazate, otherwise it will have the opposite effect.
The second question is, while using fosthiazate to control root-knot nematodes, attention should be paid to the maintenance of the root system. When the concentration offosfosthiazate is high, it has an inhibitory effect on the growth of the root system. The younger the root system, the more sensitive it is; and in the process of eliminating nematodes, the root nodule position will also be damaged. At this time, if it is not matched with root nourishing ingredients, there is a certain probability that the plant will be damaged. Stagnant growth, wilting and dead trees. I suggest here that when treating nematodes, you should use sodium nitrophenolate, brassinoids, amino acid fertilizers, etc. to promote the recovery of the root system!
The third question is, can fosthiazate be used to dip roots to control root-knot nematodes? It is not recommended to use it, because the concentration offosfosthiazate is difficult to control and the quality also varies. It may inhibit the growth of the root system and affect the normal development of crops!
The fourth question is, do not usefosthiazate continuously. The resistance of root-knot nematodes tofosthiazate is now very serious. In order to prevent root-knot nematodes, some growers have even used 10%fosthiazate granules on one acre of land. 3-5 kg, the cost is too high, the effect may not be good, and it may inhibit growth. It is recommended to use it together with avermectin or alternately with avermectin, the effect will be better!
fosthiazate (98886-44-3) Precautions
1. The use of fosthiazate cannot be in direct contact with the root system. Many fosthiazates are in granular form and can be mixed with soil and spread in the planting ditch; there are also liquid fosthiazate and avermectin compounds, which are diluted by farmers. Dipping roots is not recommended in principle, especially when the concentration is high, it will inhibit root growth.
2. Do not overuse. Blindly increasing the amount of fosthiazate used when planting tomatoes cannot effectively control nematodes. Excessive use will 100% cause damage to vegetables, ranging from slow root growth to severe growth. Stagnant leaves turn yellow. Excessive use also leads to more pesticide residues in soil and plants, or transfer to fruits, causing pollution and food problems.
3. How to use: It can be applied in ditch or acupoint, but do not spray it (broadcast application uses a large amount of medicine and the medicine is not concentrated).
4. Use fosthiazate and other chemicals alternately, apply fosthiazate in the hole before planting, and the drip irrigation line must be treated during the growth period. The control time of fosthiazate is 1-2 months, and for insurance, it is only 1 month. However, tomatoes with one crop a year or two crops a year take a long time to grow. Only one application of the agent is used to achieve the goal of no damage during the entire growing season. Nematode infection is unrealistic. Therefore, if the disease occurs during the growth period, you can use nematode biological agents for drip irrigation or flushing and root irrigation. The control period can be up to three months.
Insecticide fosthiazate (98886-44-3) price
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